KEGG   ENZYME: 2.7.8.12Help
Entry
EC 2.7.8.12                 Enzyme                                 

Name
teichoic acid poly(glycerol phosphate) polymerase;
teichoic-acid synthase;
cytidine diphosphoglycerol glycerophosphotransferase;
poly(glycerol phosphate) polymerase;
teichoic acid glycerol transferase;
glycerophosphate synthetase;
CGPTase;
CDP-glycerol glycerophosphotransferase (ambiguous);
Tag polymerase;
CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase;
tagF (gene name);
tarF (gene name) (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-glycerol:4-O-[(2R)-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Reaction(IUBMB)
n CDP-glycerol + 4-O-[(2R)-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R04042]
Reaction(KEGG)
Substrate
CDP-glycerol [CPD:C00513];
4-O-[(2R)-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Product
CMP [CPD:C00055];
4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment
Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme adds 30--50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44, teichoic acid poly(glycerol phosphate) primase. cf. EC 2.7.8.45, teichoic acid glycerol-phosphate transferase.
History
EC 2.7.8.12 created 1972, modified 1982, modified 2017
Orthology
K09809  
CDP-glycerol glycerophosphotransferase
Genes
ECC: 
HAV: 
APA: 
BTO: 
BTRE: 
BTRH: 
SACZ: 
STEK: 
PPR: 
PBPRA2712(TAGF)
PGB: 
GHO: 
PRE: 
ALT: 
HJA: 
TCY: 
HALO: 
CDN: 
CJI: 
CJSA_1365(tagF)
CJP: 
CJER: 
CJQ: 
UC78_1373(tagF)
CLA: 
CLM: 
CSM: 
CSF: 
DDE: 
DAV: 
PSF: 
BSU: 
BSU35720(tagF)
BSR: 
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSO: 
BSN: 
BSQ: 
BSX: 
C663_3464(tarF)
BSP: 
BLI: 
BL02463(tagF)
BLD: 
BLi03817(tagF)
BLH: 
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
RBAU_3424(tagF)
BAMN: 
BASU_3202(tagF)
BAMB: 
BAMT: 
BAMY: 
BMP: 
BAO: 
BAMF_3411(tagF)
BAZ: 
BQL: 
LL3_03706(tagF)
BXH: 
BQY: 
MUS_3913(tagF)
BAMI: 
BAMC: 
BAMF: 
BAE: 
BATR: 
BMYC: 
BMYO: 
BCL: 
BPU: 
BPUM: 
BPUS: 
BCK: 
BAG: 
BCOA: 
BF29_3252(tagF)
BJS: 
BLE: 
BACW: 
BACP: 
BACB: 
BACY: 
BACL: 
BALM: 
BGY: 
GEA: 
GARCT_03211(tagF_1) GARCT_03217(tagF_2)
AXL: 
TAP: 
VHL: 
VIG: 
SEP: 
SER: 
SERP1960(tagF)
SEPP: 
SEPS: 
DP17_896(tagF)
SHA: 
SH2250(tagF)
SHH: 
ShL2_02098(tarF_3)
SSP: 
SCA: 
SLG: 
SLN: 
SSD: 
SDT: 
SPSE_0280(tagF1) SPSE_0281(tagF2)
SWA: 
SPAS: 
SXY: 
SXL: 
SXO: 
SHU: 
SHYC_01830(tagF-1)
SCAP: 
AYP1020_1552(tagF_2)
SSCH: 
SSCZ: 
SAGQ: 
SEQO: 
SSIF: 
SCV: 
SHV: 
LMF: 
LMH: 
LMC: 
LMQ: 
LML: 
LMP: 
LMON: 
LMOO: 
LMOA: 
LMOL: 
LMOG: 
LMOJ: 
LMOZ: 
LMOX: 
LMOK: 
LMV: 
LIN: 
LWE: 
LIV: 
LII: 
LIW: 
LIA: 
LIO: 
ESI: 
EAN: 
EXM: 
EXU: 
PSAB: 
PLN: 
PLL: 
PANA: 
PDG: 
PHC: 
JEO: 
KUR: 
NTR: 
LLA: 
L151480(tagF)
LLK: 
LLKF_0955(tagF)
LLT: 
CVCAS_0881(tagZ) CVCAS_0882(tagY) CVCAS_0891(tagF)
LLS: 
lilo_0875(tagF)
LLD: 
LLM: 
llmg_1604(tagF)
LLN: 
LLW: 
kw2_0920(tagF)
LLJ: 
LG36_1398(tagF)
LGR: 
LGV: 
LPK: 
LPL: 
lp_0268(tagF1)
LPT: 
LPS: 
LPR: 
LPZ: 
LPB: 
LSA: 
LCA_1576(tagB)
LBR: 
LBK: 
LBH: 
LBN: 
LKO: 
LKU: 
LOR: 
LPAR: 
LPD: 
LCU: 
PPE: 
PPEN: 
PCE: 
PDM: 
PACI: 
EFA: 
EFI: 
EFN: 
EFQ: 
ENE: 
ECAS: 
MPX: 
THL: 
TEH_16260(tagF)
LCI: 
LCK_01329(tagZ)
LKI: 
LEC: 
LCN: 
LGS: 
LGE: 
WCE: 
WS08_0555(tagF_1) WS08_0779(tagF_2)
WCT: 
WS74_0556(tagF_1) WS74_0782(tagF_2)
WCI: 
WS105_0553(tagF_1) WS105_0843(tagF_2)
WCB: 
WJO: 
CPE: 
CLS: 
CLT: 
RUK: 
ESR: 
ESU: 
RCH: 
BHU: 
RIX: 
CCT: 
ROB: 
BYL: 
CPY: 
BPRL: 
HSD: 
ERH: 
ERS: 
FRO: 
ERB: 
SCO: 
SCO2590(SCC123.28)
SMA: 
SAV_5079(tagF)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCAT_4238(tagF)
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SALB: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
SAMB: 
SCZ: 
SRW: 
TUE45_03582(tagF_4)
STRF: 
SLE: 
sle_16850(sle_16850) sle_42870(sle_42870) sle_46440(sle_46440)
SPAV: 
SLC: 
STRT: 
SGS: 
STSI: 
KSK: 
LXY: 
RLA: 
RPLA: 
ARM: 
ARY: 
GAR: 
BCV: 
DNI: 
IDO: 
I598_3353(tagF_3)
CGA: 
SERJ: 
BLY: 
BLIN: 
TES: 
KFL: 
PSIM: 
TFU: 
NDA: 
NAL: 
TCU: 
SRO: 
NOA: 
GOB: 
BSD: 
KRA: 
VMA: 
AMS: 
ACTN: 
AFS: 
SNA: 
AOS: 
TBI: 
SHI: 
TSU: 
TBE: 
SGP: 
FNC: 
FSC: 
BHL: 
BCEL: 
PDN: 
FIA: 
MRU: 
MEYE: 
MOL: 
ACF: 
NAC: 
 » show all
Taxonomy
Reference
1  [PMID:14245357]
  Authors
BURGER MM, GLASER L.
  Title
THE SYNTHESIS OF TEICHOIC ACIDS. I. POLYGLYCEROPHOSPHATE.
  Journal
J. Biol. Chem. 239 (1964) 3168-77.
Reference
2  [PMID:12637499]
  Authors
Schertzer JW, Brown ED
  Title
Purified, recombinant TagF protein from Bacillus subtilis 168 catalyzes the polymerization of glycerol phosphate onto a membrane acceptor in vitro.
  Journal
J. Biol. Chem. 278 (2003) 18002-7.
Reference
3  [PMID:16141206]
  Authors
Schertzer JW, Bhavsar AP, Brown ED
  Title
Two conserved histidine residues are critical to the function of the TagF-like family of enzymes.
  Journal
J. Biol. Chem. 280 (2005) 36683-90.
Reference
4  [PMID:18465758]
  Authors
Pereira MP, Schertzer JW, D'Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED
  Title
The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III.
  Journal
Chembiochem. 9 (2008) 1385-90.
Reference
5  [PMID:19520862]
  Authors
Sewell EW, Pereira MP, Brown ED
  Title
The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis.
  Journal
J. Biol. Chem. 284 (2009) 21132-8.
Reference
6  [PMID:20400947]
  Authors
Lovering AL, Lin LY, Sewell EW, Spreter T, Brown ED, Strynadka NC
  Title
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
  Journal
Nat. Struct. Mol. Biol. 17 (2010) 582-9.
Reference
7  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem. Biol. 17 (2010) 1101-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-71-5

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