KEGG   ENZYME: 2.7.8.14Help
Entry
EC 2.7.8.14                 Enzyme                                 

Name
CDP-ribitol ribitolphosphotransferase;
teichoic-acid synthase (ambiguous);
polyribitol phosphate synthetase (ambiguous);
teichoate synthetase (ambiguous);
poly(ribitol phosphate) synthetase (ambiguous);
polyribitol phosphate polymerase (ambiguous);
teichoate synthase (ambiguous);
CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase
Reaction(IUBMB)
n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11621]
Reaction(KEGG)
Substrate
CDP-ribitol [CPD:C00789];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Product
CMP [CPD:C00055];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Comment
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.
History
EC 2.7.8.14 created 1972 as EC 2.4.1.55, transferred 1982 to EC 2.7.8.14, modified 2017
Orthology
K18704  
CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase
Genes
CSK: 
CKE: 
CJQ: 
UC78_1376(tagB)
ABL: 
BSL: 
BSY: 
BSS: 
BST: 
GYO_3936(tarL)
BSX: 
C663_3471(tarL)
BJS: 
BACY: 
SAU: 
SAV: 
SAW: 
SAH: 
SAJ: 
SAM: 
SAS: 
SAR: 
SAC: 
SAX: 
SAA: 
SAO: 
SAE: 
SAD: 
SUU: 
SUV: 
SUE: 
SUJ: 
SUK: 
SUC: 
SUT: 
SUQ: 
SUZ: 
SUD: 
SUX: 
SUW: 
SUG: 
SUF: 
SAUA: 
SAUE: 
SAUN: 
SAUS: 
SAUU: 
SAUG: 
SAUZ: 
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SAB: 
SUY: 
SAUB: 
SAUM: 
SAUC: 
SAUR: 
SAUI: 
SAUD: 
SAUF: 
SAMS: 
SUH: 
SEP: 
SER: 
SEPP: 
SEPS: 
SSP: 
SXY: 
SXL: 
SXO: 
SSCH: 
SEQO: 
SCV: 
LMO: 
LMF: 
LMH: 
LMC: 
LMN: 
LMY: 
LMT: 
LMG: 
LMS: 
LMJ: 
LMQ: 
LML: 
LMP: 
LMW: 
LMX: 
LMZ: 
LMON: 
LMOC: 
LMOS: 
LMOO: 
LMOY: 
LMOT: 
LMOA: 
LMOL: 
LMOG: 
LMOE: 
LMOB: 
LMOJ: 
LMOZ: 
LMOD: 
LMOW: 
LMOX: 
LMOQ: 
LMR: 
LMOK: 
LMV: 
LMOM: 
LIN: 
LWE: 
LSG: 
LIV: 
LII: 
LIW: 
LIA: 
LIO: 
ESI: 
EAN: 
Eab7_0180(tarL)
EXU: 
KUR: 
RST: 
LLT: 
LLS: 
lilo_0876(tagB)
LLD: 
LLM: 
llmg_1603(tagB)
LLR: 
LLN: 
LLI: 
LLW: 
kw2_0921(tagB)
LLJ: 
LG36_1397(tagB)
LGR: 
LGV: 
LPL: 
lp_1819(tarL)
LPJ: 
JDM1_1532(tagB2)
LPT: 
LPS: 
LPST_C1461(tagB2)
LPR: 
LPZ: 
LPB: 
LPX: 
PCE: 
VTE: 
VPI: 
LEC: 
WCE: 
WS08_0699(tagB)
WCT: 
WS74_0701(tagB)
WCI: 
WCB: 
CLS: 
CBV: 
RAL: 
RUS: 
RIX: 
RIM: 
HSD: 
EUU: 
ERB: 
JDE: 
XCE: 
BBI: 
BBP: 
BBF: 
SHI: 
AEQ: 
DDT: 
MEQ: 
MEB: 
MOL: 
MCUB: 
MCBB_1531(tarL)
 » show all
Taxonomy
Reference
1  [PMID:5908130]
  Authors
Ishimoto N, Strominger JL.
  Title
Polyribitol phosphate synthetase of Staphylococcus aureus.
  Journal
J. Biol. Chem. 241 (1966) 639-50.
Reference
2  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem. Biol. 15 (2008) 12-21.
  Sequence
Reference
3  [PMID:18556787]
  Authors
Pereira MP, D'Elia MA, Troczynska J, Brown ED
  Title
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.
  Journal
J. Bacteriol. 190 (2008) 5642-9.
Reference
4  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem. Biol. 17 (2010) 1101-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-71-5

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