KEGG   ENZYME: 2.7.8.17Help
Entry
EC 2.7.8.17                 Enzyme                                 

Name
UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase;
N-acetylglucosaminylphosphotransferase;
UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase;
lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
N-acetylglucosaminyl phosphotransferase;
UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [RN:R04291]
Reaction(KEGG)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
lysosomal-enzyme D-mannose [CPD:C03706]
Product
UMP [CPD:C00105];
lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04789]
Comment
Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.
History
EC 2.7.8.17 created 1984
Orthology
K08239  UDP-N-acetylglucosamine-lysosomal-enzyme
Genes
HSA: 79158(GNPTAB)
PTR: 452176(GNPTAB)
PPS: 100986324(GNPTAB)
GGO: 101124301(GNPTAB)
PON: 100441852(GNPTAB)
NLE: 100606002(GNPTAB)
MCC: 697307(GNPTAB)
MCF: 102121493(GNPTAB)
CSAB: 103238949(GNPTAB)
RRO: 104657408(GNPTAB)
RBB: 108543135(GNPTAB)
CJC: 100394765(GNPTAB) 100402714
SBQ: 101034734(GNPTAB)
MMU: 432486(Gnptab)
RNO: 362865(Gnptab)
CGE: 100774953(Gnptab)
NGI: 103733731(Gnptab)
HGL: 101710539(Gnptab)
CCAN: 109690295(Gnptab)
OCU: 100340567(GNPTAB)
TUP: 102486510(GNPTAB)
CFA: 475443(GNPTAB)
AML: 100483884(GNPTAB)
UMR: 103676570(GNPTAB)
ORO: 101376907(GNPTAB)
FCA: 101100231(GNPTAB)
PTG: 102962249(GNPTAB)
AJU: 106971899(GNPTAB)
BTA: 509610(GNPTAB)
BOM: 102269745(GNPTAB)
BIU: 109559441(GNPTAB)
PHD: 102342737(GNPTAB)
CHX: 102186936(GNPTAB)
OAS: 101122348(GNPTAB)
SSC: 100523554(GNPTAB)
CFR: 102511319(GNPTAB)
CDK: 105097459(GNPTAB)
BACU: 103017866(GNPTAB)
LVE: 103075123(GNPTAB) 103091430
OOR: 101271916(GNPTAB)
ECB: 100067011(GNPTAB)
EPZ: 103555699(GNPTAB)
EAI: 106827262(GNPTAB)
MYB: 102257362(GNPTAB)
MYD: 102766549(GNPTAB)
HAI: 109387783(GNPTAB)
RSS: 109447605(GNPTAB)
PALE: 102892520(GNPTAB)
LAV: 100668883(GNPTAB)
MDO: 100021000(GNPTAB)
SHR: 100917351(GNPTAB)
OAA: 100075585(GNPTAB)
GGA: 418096(GNPTAB)
MGP: 100546740(GNPTAB)
CJO: 107316196(GNPTAB)
APLA: 101792400(GNPTAB)
ACYG: 106031028(GNPTAB)
TGU: 100225345(GNPTAB)
GFR: 102032997(GNPTAB)
FAB: 101807127(GNPTAB)
PHI: 102114373(GNPTAB)
PMAJ: 107204412(GNPTAB)
CCW: 104696224(GNPTAB)
FPG: 101921963(GNPTAB)
FCH: 102059391(GNPTAB)
CLV: 102091116(GNPTAB)
EGZ: 104135578(GNPTAB)
AAM: 106488838(GNPTAB)
ASN: 102381964(GNPTAB)
AMJ: 102569913(GNPTAB)
PSS: 102458343(GNPTAB)
CMY: 102933760(GNPTAB)
CPIC: 101937487(GNPTAB)
ACS: 100561961(gnptab)
PVT: 110082687(GNPTAB)
PBI: 103063690(GNPTAB)
XLA: 108711016(gnptab.L) 108713209(gnptab.S)
XTR: 100036684(gnptab)
NPR: 108787158(GNPTAB)
DRE: 553365(gnptab)
IPU: 108274741(gnptab)
AMEX: 103033431(gnptab)
TRU: 101073922(gnptab)
LCO: 104926728(gnptab)
NCC: 104950103(gnptab)
MZE: 101475826(gnptab)
OLA: 101160613(gnptab)
XMA: 102234905(gnptab)
PRET: 103459179(gnptab)
NFU: 107386129(gnptab)
CSEM: 103382686(gnptab)
LCF: 108890213(gnptab)
BPEC: 110161776(gnptab)
ELS: 105030154(gnptab)
SFM: 108931544(gnptab)
LCM: 102357933(GNPTAB)
CMK: 103179873(gnptab)
CIN: 100175423(gnptab)
SPU: 100891240
APLC: 110975033
SKO: 102800521
ZNE: 110832957
TUT: 107361970
CRG: 105336164
MYI: 110450047
OBI: 106867695
EPA: 110243799
ADF: 107352997
HMG: 100199845
AQU: 100632364
BVG: 104885609
DDI: DDB_G0285815(gpt1)
DFA: DFA_06347(gpt1)
 » show all
Taxonomy
Reference
1  [PMID:6452459]
  Authors
Reitman ML, Kornfeld S.
  Title
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes.
  Journal
J. Biol. Chem. 256 (1981) 4275-81.
Reference
2  [PMID:6457829]
  Authors
Reitman ML, Kornfeld S.
  Title
Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes.
  Journal
J. Biol. Chem. 256 (1981) 11977-80.
Reference
3  [PMID:6288715]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.
  Journal
J. Biol. Chem. 257 (1982) 12322-31.
Reference
4  [PMID:6260788]
  Authors
Waheed A, Pohlmann R, Hasilik A, von Figura K.
  Title
Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes.
  Journal
J. Biol. Chem. 256 (1981) 4150-2.
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.17
IUBMB Enzyme Nomenclature: 2.7.8.17
ExPASy - ENZYME nomenclature database: 2.7.8.17
BRENDA, the Enzyme Database: 2.7.8.17
CAS: 84012-69-1

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