KEGG   ENZYME: 2.7.8.2Help
Entry
EC 2.7.8.2                  Enzyme                                 

Name
diacylglycerol cholinephosphotransferase;
phosphorylcholine-glyceride transferase;
alkylacylglycerol cholinephosphotransferase;
1-alkyl-2-acetylglycerol cholinephosphotransferase;
cholinephosphotransferase;
CPT;
alkylacylglycerol choline phosphotransferase;
diacylglycerol choline phosphotransferase;
1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase;
CDP-choline diglyceride phosphotransferase;
cytidine diphosphocholine glyceride transferase;
cytidine diphosphorylcholine diglyceride transferase;
phosphocholine diacylglyceroltransferase;
sn-1,2-diacylglycerol cholinephosphotransferase;
1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase;
CDP choline:1,2-diacylglycerol cholinephosphotransferase;
CDP-choline:1,2-diacylglycerol cholinephosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
Reaction(IUBMB)
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine [RN:R01321]
Reaction(KEGG)
Substrate
CDP-choline [CPD:C00307];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CMP [CPD:C00055];
phosphatidylcholine [CPD:C00157]
Comment
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
History
EC 2.7.8.2 created 1961, modified 1986 (EC 2.7.8.16 created 1983, incorporated 1986)
Pathway
Phosphonate and phosphinate metabolism
Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Orthology
K00994  
diacylglycerol cholinephosphotransferase
K13644  
choline/ethanolamine phosphotransferase
Genes
HSA: 
10390(CEPT1) 56994(CHPT1)
PTR: 
457116(CEPT1) 467109(CHPT1)
PPS: 
100975614(CEPT1) 100986998(CHPT1)
GGO: 
101146100(CEPT1) 101151506(CHPT1)
PON: 
100439046(CEPT1) 100440613(CHPT1)
NLE: 
100599371(CEPT1) 100605676(CHPT1)
MCC: 
696056(CHPT1) 702700(CEPT1)
MCF: 
101926162(CEPT1) 102122766(CHPT1)
CSAB: 
103224236(CEPT1) 103238948(CHPT1)
RRO: 
104657409(CHPT1) 104658945(CEPT1)
CJC: 
SBQ: 
101043338(CEPT1) 101052362(CHPT1)
MMU: 
212862(Chpt1) 99712(Cept1)
RNO: 
310773(Cept1) 362866(Chpt1)
CGE: 
100750762(Chpt1) 100773070(Cept1)
NGI: 
103733732(Chpt1) 103747803(Cept1)
HGL: 
101711138(Chpt1) 101721378(Cept1)
OCU: 
100353363(CEPT1) 100353669(CHPT1)
TUP: 
102485648(CHPT1) 102499314(CEPT1)
CFA: 
610214(CHPT1) 612948(CEPT1)
AML: 
100473311(CEPT1) 100484386(CHPT1)
UMR: 
103675028(CEPT1) 103676503(CHPT1)
FCA: 
101093451(CEPT1) 101099986(CHPT1)
PTG: 
102961960(CHPT1) 102967463(CEPT1)
BTA: 
504650(CEPT1) 511291(CHPT1)
BOM: 
102269460(CHPT1) 102273094(CEPT1)
PHD: 
102319771(CEPT1) 102339059(CHPT1)
CHX: 
102175100(CHPT1) 102182086(CEPT1)
OAS: 
101108821(CHPT1) 101112775(CEPT1)
SSC: 
100154792(CEPT1) 100523738(CHPT1)
CFR: 
102508627(CHPT1) 102513980(CEPT1)
BACU: 
102998184(CEPT1) 103018700(CHPT1)
LVE: 
103072539(CEPT1) 103085556(CHPT1)
ECB: 
100062845(CEPT1) 106782693(CHPT1)
MYB: 
MYD: 
102755578(CHPT1) 102763884(CEPT1)
PALE: 
102892767(CHPT1) 102898529(CEPT1)
LAV: 
100674609(CEPT1) 104846858(CHPT1)
MDO: 
100020969(CHPT1) 100030357(CEPT1)
SHR: 
100933929(CEPT1) 105750678(CHPT1)
OAA: 
100075425(CHPT1) 100081592(CEPT1)
GGA: 
418098(CHPT1) 421152(CEPT1)
MGP: 
CJO: 
107316205(CHPT1) 107324694(CEPT1)
APLA: 
101791878(CHPT1) 101801996(CEPT1)
TGU: 
100219217(CEPT1) 100219586(CHPT1)
GFR: 
102039926(CHPT1) 102042695(CEPT1)
FAB: 
101806735(CHPT1) 101813197(CEPT1)
PHI: 
102104902(CEPT1) 102108343(CHPT1)
CCW: 
104692467(CEPT1) 104696223(CHPT1)
FPG: 
101911330(CHPT1) 101917473(CEPT1)
FCH: 
102046063(CEPT1) 102048528(CHPT1)
CLV: 
102084659(CEPT1) 102086581(CHPT1)
AAM: 
106485642(CEPT1) 106488652(CHPT1)
ASN: 
102368380(CEPT1) 102382218(CHPT1)
AMJ: 
102560772(CEPT1) 102570848(CHPT1)
PSS: 
102458739(CHPT1) 102461379(CEPT1)
CMY: 
102933991(CHPT1) 102946218(CEPT1)
ACS: 
100561765(chpt1) 100567654(cept1)
PBI: 
103064252(CHPT1) 103064689(CEPT1)
GJA: 
107114824(CEPT1) 107119583(CHPT1)
XLA: 
379805(cept1) 734631(chpt1)
XTR: 
100216268(chpt1) 549188(cept1)
DRE: 
322605(chpt1) 570720(cept1b)
TRU: 
101078788(cept1)
TNG: 
MZE: 
OLA: 
101159156(cept1) 101173516(chpt1)
XMA: 
102225565(cept1) 102235171(chpt1)
SASA: 
LCM: 
102364240(CEPT1)
CMK: 
103179874(chpt1) 103190121(cept1)
BFO: 
CIN: 
SPU: 
SKO: 
AME: 
552795(GB10071)
TSP: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
TAD: 
SCE: 
YNL130C(CPT1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0G02370(NCAS0G02370)
NDI: 
NDAI_0B04390(NDAI0B04390) NDAI_0F02920(NDAI0F02920)
TPF: 
TPHA_0I01400(TPHA0I01400)
TBL: 
TBLA_0B01190(TBLA0B01190) TBLA_0D00380(TBLA0D00380)
TDL: 
TDEL_0B05000(TDEL0B05000)
KAF: 
KAFR_0F00670(KAFR0F00670) KAFR_0J02190(KAFR0J02190)
PPA: 
SRE: 
SPAR: 
 » show all
Taxonomy
Reference
1  [PMID:192727]
  Authors
Coleman R, Bell RM.
  Title
Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.
  Journal
J. Biol. Chem. 252 (1977) 3050-6.
Reference
2  [PMID:6295501]
  Authors
Lee TC, Blank ML, Fitzgerald V, Snyder F.
  Title
Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver.
  Journal
Biochim. Biophys. Acta. 713 (1982) 479-83.
Reference
3  [PMID:204847]
  Authors
Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ.
  Title
Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate.
  Journal
Lipids. 13 (1978) 161-4.
Reference
4  [PMID:6260215]
  Authors
Renooij W, Snyder F.
  Title
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues.
  Journal
Biochim. Biophys. Acta. 663 (1981) 545-56.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-13-5

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