KEGG   ENZYME: 2.7.8.23Help
Entry
EC 2.7.8.23                 Enzyme                                 

Name
carboxyvinyl-carboxyphosphonate phosphorylmutase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Reaction(IUBMB)
1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2 [RN:R05165]
Reaction(KEGG)
R05165;
(other) R08868 R08869
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Substrate
1-carboxyvinyl carboxyphosphonate [CPD:C06367]
Product
3-(hydrohydroxyphosphoryl)pyruvate [CPD:C06368];
CO2 [CPD:C00011]
Comment
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
History
EC 2.7.8.23 created 1999
Reference
1  [PMID:1330557]
  Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR.
  Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
  Journal
Eur. J. Biochem. 209 (1992) 735-43.
  Sequence
Reference
2  [PMID:3611020]
  Authors
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ.
  Title
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
  Journal
J. Bacteriol. 169 (1987) 3482-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122799-57-9

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