triphosphoribosyl-dephospho-CoA synthase;
2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase;
ATP:dephospho-CoA 5-triphosphoribosyl transferase;
CitG;
ATP:dephospho-CoA 5'-triphosphoribosyl transferase;
MdcB;
ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase;
MadG

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

ATP:3'-dephospho-CoA 5-triphosphoribosyltransferase

ATP + 3'-dephospho-CoA = 2'-(5-triphosphoribosyl)-3'-dephospho-CoA + adenine [RN:R09675]

R09675

ATP [CPD:C00002];
3'-dephospho-CoA [CPD:C00882]

ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].

1  [PMID:10924139]

Schneider K, Dimroth P, Bott M.

Biosynthesis of the prosthetic group of citrate lyase.

Biochemistry. 39 (2000) 9438-50.

Escherichia coli [GN:eco], Klebsiella pneumoniae [GN:kpn]

2  [PMID:11042274]

Schneider K, Dimroth P, Bott M.

Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.

FEBS. Lett. 483 (2000) 165-8.

Escherichia coli [GN:eco]

3  [PMID:11948157]

Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M.

Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.

J. Bacteriol. 184 (2002) 2439-46.

Escherichia coli [GN:eco], Klebsiella pneumoniae [GN:kpn]

4  [PMID:11052675]

Hoenke S, Wild MR, Dimroth P.

Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase.

Biochemistry. 39 (2000) 13223-32.

Klebsiella pneumoniae [GN:kpn]