KEGG   ENZYME: 2.7.8.29Help
Entry
EC 2.7.8.29                 Enzyme                                 
Name
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
Reaction(IUBMB)
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN:R07376]
Reaction(KEGG)
Substrate
L-1-phosphatidylethanolamine [CPD:C00350];
L-serine [CPD:C00065]
Product
L-1-phosphatidylserine [CPD:C02737];
ethanolamine [CPD:C00189]
Comment
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
Pathway
Glycerophospholipid metabolism
Metabolic pathways
Orthology
K08730  
phosphatidylserine synthase 2
Genes
HSA: 
81490(PTDSS2)
PTR: 
739066(PTDSS2)
PPS: 
100994862(PTDSS2)
GGO: 
101132603(PTDSS2)
PON: 
100458699(PTDSS2)
MCC: 
698582(PTDSS2)
MMU: 
27388(Ptdss2)
RNO: 
293620(Ptdss2)
CFA: 
483401(PTDSS2)
AML: 
FCA: 
101085320(PTDSS2)
BTA: 
529829(PTDSS2)
ECB: 
100054404(PTDSS2)
SHR: 
100921197(PTDSS2)
GGA: 
422997(PTDSS1)
MGP: 
100540844(PTDSS2)
TGU: 
100229553(PTDSS2)
ACS: 
100567634(ptdss2)
XLA: 
100190774(ptdss2)
XTR: 
780129(ptdss2)
DRE: 
100004136(ptdss2)
TRU: 
101080052
OLA: 
101164977
BFO: 
BRAFLDRAFT_201014
CIN: 
100184878
SPU: 
100890899
SMM: 
Smp_125780(pss2)
NVE: 
NEMVE_v1g159004
AQU: 
100636278
ATH: 
AT1G15110
ALY: 
ARALYDRAFT_471699
GMX: 
100787048 100802199
CSV: 
101205141 101208533 101226522
RCU: 
RCOM_0577720
POP: 
POPTR_564577 POPTR_882758
VVI: 
100261188 100266447
OSA: 
4339554
DOSA: 
Os05t0554400-01(Os05g0554400)
BDI: 
100833489 100836759
SBI: 
SORBI_03g008030(SORBIDRAFT_03g008030) SORBI_09g027850(SORBIDRAFT_09g027850)
ZMA: 
100216715 100283193
SMO: 
SELMODRAFT_121992 SELMODRAFT_92791
PPP: 
PHYPADRAFT_115306 PHYPADRAFT_191269
OLU: 
OSTLU_3295
OTA: 
Ot11g01270
LBC: 
LACBIDRAFT_312044
CCI: 
CC1G_08005
SCM: 
SCHCODRAFT_15042
PGR: 
PGTG_02227
NGR: 
NAEGRDRAFT_82113
DDI: 
DDB_G0278159(pssA)
DPP: 
DICPUDRAFT_37736
EHI: 
EHI_009800(4.t00097)
EDI: 
EDI_100190
PCB: 
PC000559.02.0
PKN: 
PKH_110380
PVX: 
PVX_115300
PCY: 
PCYB_111370
TET: 
TTHERM_00190960
TCR: 
506795.40
PIF: 
PITG_00570
 » show all
Taxonomy
Reference
1  [PMID:10432300]
  Authors
Stone SJ, Vance JE
  Title
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.
  Journal
Biochem. J. 342 ( Pt 1) (1999) 57-64.
Reference
2  [PMID:19014349]
  Authors
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O
  Title
Purification and characterization of human phosphatidylserine synthases 1 and 2.
  Journal
Biochem. J. 418 (2009) 421-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system