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Entry
EC 2.7.8.29                 Enzyme                                 

Name
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
Reaction(IUBMB)
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN:R07376]
Reaction(KEGG)
Substrate
L-1-phosphatidylethanolamine [CPD:C00350];
L-serine [CPD:C00065]
Product
L-1-phosphatidylserine [CPD:C02737];
ethanolamine [CPD:C00189]
Comment
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
History
EC 2.7.8.29 created 2010
Pathway
Glycerophospholipid metabolism
Metabolic pathways
Orthology
K08730  
phosphatidylserine synthase 2
Genes
HSA: 
81490(PTDSS2)
PTR: 
739066(PTDSS2)
PPS: 
100994862(PTDSS2)
GGO: 
101132603(PTDSS2)
PON: 
100458699(PTDSS2)
NLE: 
100603636(PTDSS2)
MCC: 
698582(PTDSS2)
MCF: 
102117045(PTDSS2)
CJC: 
100412047(PTDSS2)
MMU: 
27388(Ptdss2)
RNO: 
293620(Ptdss2)
CGE: 
NGI: 
103751073(Ptdss2)
HGL: 
101716975(Ptdss2)
OCU: 
103347505(PTDSS2)
TUP: 
102474211(PTDSS2)
CFA: 
483401(PTDSS2)
AML: 
UMR: 
103671087(PTDSS2)
FCA: 
101085320(PTDSS2)
PTG: 
102951536(PTDSS2)
BTA: 
529829(PTDSS2)
BOM: 
102283385(PTDSS2)
OAS: 
BACU: 
103000053(PTDSS2)
LVE: 
103072335(PTDSS2)
ECB: 
100054404(PTDSS2)
MYB: 
102245359(PTDSS2)
MYD: 
102762251(PTDSS2)
PALE: 
102895742(PTDSS2)
SHR: 
100921197(PTDSS2)
GGA: 
422997(PTDSS2)
MGP: 
100540844(PTDSS2)
APLA: 
TGU: 
100229553(PTDSS2)
FAB: 
101807502(PTDSS2)
PHI: 
102106200(PTDSS2)
FPG: 
101915281(PTDSS2)
FCH: 
102049262(PTDSS2)
CLV: 
102088455(PTDSS2)
ASN: 
102384840(PTDSS2)
AMJ: 
102568801(PTDSS2)
PSS: 
102450192(PTDSS2)
CMY: 
102929824(PTDSS2)
ACS: 
100567634(ptdss2)
PBI: 
XLA: 
100190774(ptdss2)
XTR: 
780129(ptdss2)
DRE: 
100004136(ptdss2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103186012(ptdss2)
BFO: 
CIN: 
SPU: 
HRO: 
LGI: 
SMM: 
NVE: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0008s12500g(POPTRDRAFT_564577) POPTR_0010s12770g(POPTRDRAFT_882758)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0118300-01(Os01g0118300) Os05t0554400-01(Os05g0554400)
OBR: 
BDI: 
SBI: 
SORBI_03g008030(SORBIDRAFT_03g008030) SORBI_09g027850(SORBIDRAFT_09g027850)
ZMA: 
SITA: 
PDA: 
ATR: 
s00006p00177250(AMTR_s00006p00177250)
SMO: 
PPP: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT74777(AGABI1DRAFT_74777)
ABV: 
AGABI2DRAFT224623(AGABI2DRAFT_224623)
CPUT: 
SLA: 
PGR: 
MLR: 
DDI: 
DPP: 
DFA: 
DFA_00831(pssA)
EHI: 
EHI_009800(4.t00097)
EDI: 
ACAN: 
PFA: 
PFH: 
PCB: 
PKN: 
PVX: 
PCY: 
TET: 
PTM: 
PIF: 
GTT: 
TCR: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:10432300]
  Authors
Stone SJ, Vance JE
  Title
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.
  Journal
Biochem. J. 342 ( Pt 1) (1999) 57-64.
  Sequence
[mmu:19210 27388]
Reference
2  [PMID:19014349]
  Authors
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O
  Title
Purification and characterization of human phosphatidylserine synthases 1 and 2.
  Journal
Biochem. J. 418 (2009) 421-9.
  Sequence
[hsa:9791 81490]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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