KEGG   ENZYME: 2.7.8.35Help
Entry
EC 2.7.8.35                 Enzyme                                 

Name
UDP-N-acetylglucosamine---decaprenyl-phosphate N-acetylglucosaminephosphotransferase;
GlcNAc-1-phosphate transferase;
UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase;
WecA;
WecA transferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:trans,octacis-decaprenyl-phosphate N-acetylglucosaminephosphotransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [RN:R10137]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
trans,octacis-decaprenyl phosphate [CPD:C02970]
Product
UMP [CPD:C00105];
N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:C20390]
Comment
Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
History
EC 2.7.8.35 created 2012
Reference
1  [PMID:20637039]
  Authors
Jin Y, Xin Y, Zhang W, Ma Y
  Title
Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis.
  Journal
FEMS. Microbiol. Lett. 310 (2010) 54-61.
  Sequence
[msm:MSMEG_4947] [mtu:Rv1302]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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