KEGG   ENZYME: 2.8.1.3Help
Entry
EC 2.8.1.3                  Enzyme                                 

Name
thiosulfate---thiol sulfurtransferase;
glutathione-dependent thiosulfate reductase;
sulfane reductase;
sulfane sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
thiosulfate:thiol sulfurtransferase
Reaction(IUBMB)
thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide [RN:R01875]
Reaction(KEGG)
Substrate
thiosulfate [CPD:C00320];
glutathione [CPD:C00051]
Product
sulfite [CPD:C00094];
glutathione disulfide [CPD:C00127];
sulfide [CPD:C00283]
Comment
The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.
History
EC 2.8.1.3 created 1982
Pathway
Glutathione metabolism
Reference
1  [PMID:14484816]
  Authors
PECK HD Jr, FISHER E Jr.
  Title
The oxidation of thiosulfate and phosphorylation in extracts of Thiobacillus thioparus.
  Journal
J. Biol. Chem. 237 (1962) 190-7.
  Organism
Thiobacillus thioparus
Reference
2
  Authors
Sido, B. and Koj, A.
  Title
Separation of rhodanese and thiosulfate reductase activities in carp liver extracts.
  Journal
Acta Biol. Cracow Ser. Zoo. 15 (1972) 97-103.
Reference
3  [PMID:383018]
  Authors
Uhteg LC, Westley J.
  Title
Purification and steady-state kinetic analysis of yeast thiosulfate reductase.
  Journal
Arch. Biochem. Biophys. 195 (1979) 211-22.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
111070-24-7

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