KEGG   ENZYME: 2.8.1.4Help
Entry
EC 2.8.1.4                  Enzyme                                 

Name
tRNA sulfurtransferase;
transfer ribonucleate sulfurtransferase;
RNA sulfurtransferase;
ribonucleate sulfurtransferase;
transfer RNA sulfurtransferase;
transfer RNA thiolase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
L-cysteine:tRNA sulfurtransferase
Reaction(IUBMB)
L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide [RN:R03923]
Reaction(KEGG)
R03923;
(other) R08700
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Substrate
L-cysteine [CPD:C00097];
'activated' tRNA [CPD:C02342]
Product
L-serine [CPD:C00065];
tRNA containing a thionucleotide [CPD:C04161]
Comment
A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor.
History
EC 2.8.1.4 created 1984
Reference
1  [PMID:5541999]
  Authors
Abrell JW, Kaufman EE, Lipsett MN.
  Title
The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system.
  Journal
J. Biol. Chem. 246 (1971) 294-301.
  Organism
Escherichia coli
Reference
2  [PMID:5334200]
  Authors
Hayward RS, Weiss SB.
  Title
RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 55 (1966) 1161-8.
  Organism
Escherichia coli
Reference
3  [PMID:5334201]
  Authors
Lipsett MN, Peterkofsky A.
  Title
Enzymatic thiolation of E. coli sRNA.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 55 (1966) 1169-74.
  Organism
Escherichia coli
Reference
4  [PMID:4987417]
  Authors
Wong TW, Weiss SB, Eliceiri GL, Bryant J.
  Title
Ribonucleic acid sulfurtransferase from Bacillus subtilis W168. Sulfuration with beta-mercaptopyruvate and properties of the enzyme system.
  Journal
Biochemistry. 9 (1970) 2376-86.
  Organism
Bacillus subtilis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9055-57-6

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