KEGG   ENZYME: 2.8.1.5Help
Entry
EC 2.8.1.5                  Enzyme                                 

Name
thiosulfate---dithiol sulfurtransferase;
thiosulfate reductase;
TSR
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
thiosulfate:dithioerythritol sulfurtransferase
Reaction(IUBMB)
thiosulfate + dithioerythritol = sulfite + 4,5-cis-dihydroxy-1,2-dithiacyclohexane (i.e. oxidized dithioerythritol) + sulfide [RN:R05072]
Reaction(KEGG)
Substrate
thiosulfate [CPD:C00320];
dithioerythritol [CPD:C00950]
Product
sulfite [CPD:C00094];
4,5-cis-dihydroxy-1,2-dithiacyclohexane [CPD:C06484];
sulfide [CPD:C00283]
Comment
The enzyme from Chlorella shows very little activity towards monothiols such as glutathione and cysteine (cf. EC 2.8.1.3 thiosulfate---thiolsulfurtransferase). The enzyme probably transfers the sulfur atom onto one thiol group to form -S-S-, and sulfide is spontaneously expelled from this by reaction with the other thiol group. May be identical with EC 2.8.1.1 thiosulfate sulfurtransferase.
History
EC 2.8.1.5 created 1989, modified 1999
Pathway
Sulfur metabolism
Microbial metabolism in diverse environments
Reference
1
  Authors
Schmidt, A., Erdle, I. and Gamon, B.
  Title
Isolation and characterization of thiosulfate reductases from the green alga Chlorella fusca.
  Journal
Planta 162 (1984) 243-249.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-49-8

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