KEGG   ENZYME: 2.8.2.17Help
Entry
EC 2.8.2.17                 Enzyme                                 
Name
chondroitin 6-sulfotransferase;
chondroitin 6-O-sulfotransferase;
3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase;
terminal 6-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate [RN:R02181]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 6'-sulfate [CPD:C00635]
Comment
The sulfation is at the 6-position of N-acetylgalactosamine residues of chondroitin. Not identical with EC 2.8.2.5 chondroitin 4-sulfotransferase.
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K01020  
chondroitin 6-sulfotransferase 3
K04743  
chondroitin 6-sulfotransferase 7
Genes
HSA: 
56548(CHST7) 9469(CHST3)
PTR: 
466290(CHST3)
PPS: 
100985655(CHST3) 100985832(CHST7)
GGO: 
101125111(CHST7) 101148104(CHST3)
PON: 
100435256(CHST7) 100436913(CHST3)
MCC: 
704906(CHST7) 709333(CHST3)
MMU: 
53374(Chst3) 60322(Chst7)
RNO: 
302302(Chst7) 84468(Chst3)
CFA: 
100855759(CHST3) 491852(CHST7)
AML: 
FCA: 
101080828(CHST3) 101089584(CHST7)
BTA: 
506758(CHST3) 540357(CHST7)
SSC: 
100151968(CHST3) 100521649
ECB: 
100063554(CHST3)
MDO: 
100010061(CHST3) 100011790(CHST7)
SHR: 
100923076 100932909(CHST3)
GGA: 
396018(CHST3)
MGP: 
100543982
TGU: 
100229231
ACS: 
100568098
XLA: 
734885(chst7)
XTR: 
100379720(chst7) 100492673
DRE: 
556800(chst3b) 559721 563748
TRU: 
101064718 101077764 101080112
OLA: 
101155457 101162162 101170173
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim. Biophys. Acta. 717 (1982) 414-21.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37292-93-6
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