KEGG   ENZYME: 2.8.2.21Help
Entry
EC 2.8.2.21                 Enzyme                                 

Name
keratan sulfotransferase;
3'-phosphoadenylyl keratan sulfotransferase;
keratan sulfate sulfotransferase;
3'-phosphoadenylylsulfate:keratan sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate [RN:R03553]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
keratan [CPD:C00573]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
keratan 6'-sulfate [CPD:C00573]
Comment
Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase).
History
EC 2.8.2.21 created 1989
Pathway
Glycosaminoglycan biosynthesis - keratan sulfate
Orthology
K01022  
keratan sulfate 6-sulfotransferase 1
Genes
HSA: 
8534(CHST1)
PTR: 
466500(CHST1)
PPS: 
100979080(CHST1)
GGO: 
101136055(CHST1)
PON: 
100460062(CHST1)
NLE: 
100607513(CHST1)
MCC: 
715176(CHST1)
MCF: 
102121159(CHST1)
CSAB: 
103236789(CHST1)
RRO: 
104668375(CHST1)
CJC: 
100403467(CHST1)
SBQ: 
101041677(CHST1)
MMU: 
76969(Chst1)
RNO: 
295934(Chst1)
CGE: 
100774066(Chst1)
NGI: 
103751543(Chst1)
HGL: 
101709273(Chst1)
OCU: 
100348291(CHST1)
TUP: 
102494285(CHST1)
CFA: 
483642(CHST1)
AML: 
100472620(CHST1)
UMR: 
103672398(CHST1)
FCA: 
101085495(CHST1)
PTG: 
102972740(CHST1)
BTA: 
506932(CHST1)
BOM: 
102269216(CHST1)
PHD: 
102326729(CHST1)
CHX: 
102182814(CHST1)
OAS: 
101112159(CHST1)
SSC: 
100519885(CHST1)
CFR: 
102507446(CHST1)
BACU: 
103002842(CHST1)
LVE: 
103089266(CHST1)
ECB: 
106780839(CHST1)
MYB: 
MYD: 
102766961(CHST1)
PALE: 
102892829(CHST1)
LAV: 
100654881(CHST1)
MDO: 
100011264(CHST1)
OAA: 
100074919(CHST1)
GGA: 
428866(CHST1)
MGP: 
100550392(CHST1)
CJO: 
107314790(CHST1)
APLA: 
101796672(CHST1)
TGU: 
100218131(CHST1)
GFR: 
102031769(CHST1)
FAB: 
101821527(CHST1)
PHI: 
102102314(CHST1)
CCW: 
104698272(CHST1)
FPG: 
101914171(CHST1)
FCH: 
102059692(CHST1)
CLV: 
102090832(CHST1)
AAM: 
106498277(CHST1)
ASN: 
102377269(CHST1)
AMJ: 
102576487(CHST1)
PSS: 
102450260(CHST1)
CMY: 
102947896(CHST1)
ACS: 
100556876(chst1)
PBI: 
103058223(CHST1)
GJA: 
107113395(CHST1)
XTR: 
100492654(chst1)
DRE: 
445124(chst1)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
ISC: 
LGI: 
CRG: 
NVE: 
ADF: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:6592165]
  Authors
Ruter ER, Kresse H.
  Title
Partial purification and characterization of 3'-phosphoadenylylsulfate:keratan sulfate sulfotransferases.
  Journal
J. Biol. Chem. 259 (1984) 11771-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62168-79-0

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