KEGG   ENZYME: 2.8.2.22Help
Entry
EC 2.8.2.22                 Enzyme                                 
Name
aryl-sulfate sulfotransferase;
arylsulfate-phenol sulfotransferase;
arylsulfotransferase;
ASST;
arylsulfate sulfotransferase;
arylsulfate:phenol sulfotransferase;
astA (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
aryl-sulfate:phenol sulfotransferase
Reaction(IUBMB)
an aryl sulfate + a phenol = a phenol + an aryl sulfate
Reaction(KEGG)
(other) R02996
Show
Substrate
aryl sulfate [CPD:C00850];
phenol [CPD:C00146]
Product
phenol [CPD:C00146];
aryl sulfate [CPD:C00850]
Comment
The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ [1]. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate [1].
The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors [2]. The reaction proceeds according to a ping pong bi bi mechanism [6].
Orthology
K01023  
arylsulfate sulfotransferase
Genes
ECG: 
ECC: 
c3785(asst)
ECP: 
ECI: 
ECV: 
ECM: 
ECQ: 
EUM: 
ECZ: 
EFE: 
EFER_2980(assT)
STY: 
STY3370(assT)
STT: 
t3112(assT)
STM: 
STM3191
SPT: 
SPA3060(assT)
SEK: 
SSPA2856
SPQ: 
SPAB_03985
SEI: 
SPC_3266(assT)
SEC: 
SC3136(astJ)
SEH: 
SeHA_C3443
SEE: 
SNSL254_A3450
SEW: 
SeSA_A3378
SEA: 
SeAg_B3373
SED: 
SeD_A3545
SEG: 
SG3088
SET: 
SEN3034
SES: 
SARI_04436
CRO: 
ROD_35871(assT)
EIC: 
NT01EI_0602
ETR: 
ETAE_0524(assT)
PEN: 
PSEEN0187
SON: 
SO_3872(assT)
SSE: 
Ssed_0237 Ssed_4001
SPL: 
Spea_4022
SHL: 
Shal_0236
SWP: 
swp_4147
FBL: 
Fbal_0078
CJJ: 
CJJ81176_0882
CFF: 
CFF8240_0436
CCV: 
CCV52592_0844 CCV52592_1149
CCO: 
CCC13826_0901
GME: 
Gmet_1382
DPR: 
Despr_1642
LSG: 
lse_1957(astA)
LPL: 
lp_1381(astA)
LPJ: 
JDM1_1159(astA)
LSA: 
LSA0090 LSA0091
LBR: 
LVIS_2143
AUR: 
HMPREF9243_1609
DSY: 
DSY2571
DHD: 
Dhaf_3734
BHY: 
BHWA1_01792
BRM: 
Bmur_1462 Bmur_1825
BPO: 
BP951000_1092
BVU: 
BVU_0583
FBC: 
FB2170_04585
CAO: 
Celal_3865
 » show all
Taxonomy
Reference
1  [PMID:3460636]
  Authors
Kim DH, Konishi L, Kobashi K.
  Title
Purification, characterization and reaction mechanism of novel arylsulfotransferase obtained from an anaerobic bacterium of human intestine.
  Journal
Biochim. Biophys. Acta. 872 (1986) 33-41.
  Organism
Homo sapiens [GN:hsa]
Reference
2
  Authors
Kobashi, K., Kim, D.-H. and Morikawa, T.
  Title
A novel type of arylsulfotransferase.
  Journal
J. Protein Chem. 6 (1987) 237-244.
Reference
3  [PMID:2347024]
  Authors
Koizumi M, Shimizu M, Kobashi K
  Title
Enzymatic sulfation of quercetin by arylsulfotransferase from a human intestinal  bacterium.
  Journal
Chem. Pharm. Bull. (Tokyo). 38 (1990) 794-6.
Reference
4  [PMID:1806284]
  Authors
Koizumi M, Akao T, Kadota S, Kikuchi T, Okuda T, Kobashi K
  Title
Enzymatic sulfation of polyphenols related to tannins by arylsulfotransferase.
  Journal
Chem. Pharm. Bull. (Tokyo). 39 (1991) 2638-43.
Reference
5  [PMID:7820100]
  Authors
Konishi-Imamura L, Sato M, Dohi K, Kadota S, Namba T, Kobashi K
  Title
Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium.
  Journal
Biol. Pharm. Bull. 17 (1994) 1018-22.
Reference
6  [PMID:8576095]
  Authors
Lee NS, Kim BT, Kim DH, Kobashi K
  Title
Purification and reaction mechanism of arylsulfate sulfotransferase from Haemophilus K-12, a mouse intestinal bacterium.
  Journal
J. Biochem. 118 (1995) 796-801.
Reference
7  [PMID:17202651]
  Authors
Kim B, Hyun YJ, Lee KS, Kobashi K, Kim DH
  Title
Cloning, expression and purification of arylsulfate sulfotransferase from Eubacterium A-44.
  Journal
Biol. Pharm. Bull. 30 (2007) 11-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
158254-86-5
DBGET integrated database retrieval system