KEGG   ENZYME: 2.8.2.22Help
Entry
EC 2.8.2.22                 Enzyme                                 

Name
aryl-sulfate sulfotransferase;
arylsulfate-phenol sulfotransferase;
arylsulfotransferase;
ASST;
arylsulfate sulfotransferase;
arylsulfate:phenol sulfotransferase;
astA (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
aryl-sulfate:phenol sulfotransferase
Reaction(IUBMB)
an aryl sulfate + a phenol = a phenol + an aryl sulfate
Reaction(KEGG)
(other) R02996
Show
Substrate
aryl sulfate [CPD:C00850];
phenol [CPD:C15584]
Product
phenol [CPD:C15584];
aryl sulfate [CPD:C00850]
Comment
The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ [1]. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate [1].
The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors [2]. The reaction proceeds according to a ping pong bi bi mechanism [6].
History
EC 2.8.2.22 created 1990
Orthology
K01023  
arylsulfate sulfotransferase
Genes
ECG: 
ECC: 
c3785(asst)
ECP: 
ECI: 
ECV: 
ECM: 
ECQ: 
EUM: 
ECZ: 
ELO: 
ELN: 
ESE: 
EAB: 
EIH: 
ENA: 
ELU: 
ELC: 
i14_3479(asst)
ELD: 
i02_3479(asst)
ELF: 
ECOI: 
ECOJ: 
EFE: 
EFER_2980(assT)
EAL: 
STY: 
STY3370(assT)
STT: 
t3112(assT)
SEX: 
SENT: 
SEO: 
SEV: 
SEY: 
SEJ: 
SEB: 
SEF: 
SETC: 
SENR: 
SENI: 
SEEN: 
SPT: 
SPA3060(assT)
SEK: 
SPQ: 
SEI: 
SPC_3266(assT)
SEC: 
SCH_3136(astJ)
SEH: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SEG: 
SEL: 
SEGA: 
SET: 
SENA: 
SENO: 
SENV: 
SENQ: 
SENL: 
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
SENE: 
SENC: 
SES: 
SBZ: 
SBV: 
CRO: 
ROD_35871(assT)
EIC: 
ETR: 
ETAE_0524(assT)
ETD: 
ETE: 
ETC: 
EDW: 
EDL: 
CEN: 
PEN: 
SON: 
SO_3872(assT)
SSE: 
SPL: 
SHL: 
SWP: 
FBL: 
CJJ: 
CFF: 
CCV: 
CCO: 
CGRA: 
GME: 
DPR: 
LSG: 
lse_1957(astA)
LPL: 
lp_1381(astA)
LPJ: 
JDM1_1159(astA)
LSA: 
LBR: 
AUR: 
DSY: 
DHD: 
BHY: 
BRM: 
BPO: 
BVU: 
FBC: 
CAO: 
 » show all
Taxonomy
Reference
1  [PMID:3460636]
  Authors
Kim DH, Konishi L, Kobashi K.
  Title
Purification, characterization and reaction mechanism of novel arylsulfotransferase obtained from an anaerobic bacterium of human intestine.
  Journal
Biochim. Biophys. Acta. 872 (1986) 33-41.
Reference
2
  Authors
Kobashi, K., Kim, D.-H. and Morikawa, T.
  Title
A novel type of arylsulfotransferase.
  Journal
J. Protein Chem. 6 (1987) 237-244.
Reference
3  [PMID:2347024]
  Authors
Koizumi M, Shimizu M, Kobashi K
  Title
Enzymatic sulfation of quercetin by arylsulfotransferase from a human intestinal  bacterium.
  Journal
Chem. Pharm. Bull. (Tokyo). 38 (1990) 794-6.
Reference
4  [PMID:1806284]
  Authors
Koizumi M, Akao T, Kadota S, Kikuchi T, Okuda T, Kobashi K
  Title
Enzymatic sulfation of polyphenols related to tannins by arylsulfotransferase.
  Journal
Chem. Pharm. Bull. (Tokyo). 39 (1991) 2638-43.
Reference
5  [PMID:7820100]
  Authors
Konishi-Imamura L, Sato M, Dohi K, Kadota S, Namba T, Kobashi K
  Title
Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium.
  Journal
Biol. Pharm. Bull. 17 (1994) 1018-22.
Reference
6  [PMID:8576095]
  Authors
Lee NS, Kim BT, Kim DH, Kobashi K
  Title
Purification and reaction mechanism of arylsulfate sulfotransferase from Haemophilus K-12, a mouse intestinal bacterium.
  Journal
J. Biochem. 118 (1995) 796-801.
Reference
7  [PMID:17202651]
  Authors
Kim B, Hyun YJ, Lee KS, Kobashi K, Kim DH
  Title
Cloning, expression and purification of arylsulfate sulfotransferase from Eubacterium A-44.
  Journal
Biol. Pharm. Bull. 30 (2007) 11-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
158254-86-5

DBGET integrated database retrieval system