KEGG   ENZYME: 2.8.2.29Help
Entry
EC 2.8.2.29                 Enzyme                                 

Name
[heparan sulfate]-glucosamine 3-sulfotransferase 2;
glucosaminyl 3-O-sulfotransferase;
heparan sulfate D-glucosaminyl 3-O-sulfotransferase;
isoform/isozyme 2 (3-OST-2, HS3ST2)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]
Comment
This enzyme sulfates the residues marked with an asterisk in sequences containing at least -> IdoA2S-> GlcN*-> or -> GlcA2S-> GlcN*-> (symbols as in {iupac/2carb/38::2-Carb-38}). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S.
History
EC 2.8.2.29 created 2001
Pathway
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K07808  
[heparan sulfate]-glucosamine 3-sulfotransferase 2
Genes
HSA: 
9956(HS3ST2)
PTR: 
467924(HS3ST2)
PPS: 
100969271(HS3ST2)
GGO: 
101138321(HS3ST2)
PON: 
100459958(HS3ST2)
NLE: 
100590606(HS3ST2)
MCC: 
699722(HS3ST2)
MCF: 
102143244(HS3ST2)
RRO: 
104658241(HS3ST2)
CJC: 
100405177(HS3ST2)
MMU: 
195646(Hs3st2)
RNO: 
293451(Hs3st2)
CGE: 
100765580(Hs3st2)
NGI: 
103742741(Hs3st2)
HGL: 
101715838(Hs3st2)
OCU: 
100349071(HS3ST2)
TUP: 
102470961(HS3ST2)
CFA: 
489975(HS3ST2)
AML: 
100475753(HS3ST2)
UMR: 
103668867(HS3ST2)
FCA: 
101090732(HS3ST2)
PTG: 
102955706(HS3ST2)
BTA: 
532099(HS3ST2)
BOM: 
102266030(HS3ST2)
PHD: 
102339420(HS3ST2)
CHX: 
102183286(HS3ST2)
OAS: 
101116370(HS3ST2)
SSC: 
100522426(HS3ST2)
CFR: 
102517676(HS3ST2)
BACU: 
103004974(HS3ST2)
LVE: 
103086879(HS3ST2)
ECB: 
100068342(HS3ST2)
MYB: 
102257576(HS3ST2)
MYD: 
102760096(HS3ST2)
PALE: 
102883217(HS3ST2)
MDO: 
100019945(HS3ST2)
SHR: 
100914793(HS3ST2)
OAA: 
GGA: 
416581(HS3ST2)
MGP: 
100540809(HS3ST2)
CJO: 
107320809(HS3ST2)
APLA: 
101800694(HS3ST2)
TGU: 
100222527(HS3ST2)
GFR: 
FAB: 
101808999(HS3ST2)
PHI: 
102113866(HS3ST2)
CCW: 
104684726(HS3ST2)
FPG: 
101913235(HS3ST2)
FCH: 
102054410(HS3ST2)
CLV: 
102088439(HS3ST2)
AAM: 
106487617(HS3ST2)
ASN: 
102371657(HS3ST2)
AMJ: 
102563033(HS3ST2)
PSS: 
CMY: 
102932960(HS3ST2)
ACS: 
PBI: 
103064628(HS3ST2)
GJA: 
107126204(HS3ST2)
XTR: 
100492586(hs3st2)
DRE: 
571246(hs3st2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347024(HS3ST2)
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:9988767]
  Authors
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.
  Title
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
  Journal
J. Biol. Chem. 274 (1999) 5170-84.
  Sequence
[hsa:9956]
Reference
2  [PMID:9988768]
  Authors
Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD.
  Title
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.
  Journal
J. Biol. Chem. 274 (1999) 5185-92.
  Sequence
[hsa:9956]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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