KEGG   ENZYME: 2.8.2.30Help
Entry
EC 2.8.2.30                 Enzyme                                 

Name
[heparan sulfate]-glucosamine 3-sulfotransferase 3
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]
Comment
Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)].
History
EC 2.8.2.30 created 2001
Pathway
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K07809  
[heparan sulfate]-glucosamine 3-sulfotransferase 3
Genes
HSA: 
9953(HS3ST3B1) 9955(HS3ST3A1)
PTR: 
455061(HS3ST3A1) 468393(HS3ST3B1)
PPS: 
100974193(HS3ST3A1) 100988267(HS3ST3B1)
GGO: 
101145926(HS3ST3A1) 101151182(HS3ST3B1)
PON: 
100442248(HS3ST3B1)
NLE: 
100586137(HS3ST3A1) 100589938(HS3ST3B1)
MCC: 
718232(HS3ST3A1)
MCF: 
102131170(HS3ST3A1) 102135242(HS3ST3B1)
CSAB: 
103242411(HS3ST3A1) 103242418(HS3ST3B1)
RRO: 
104667951(HS3ST3A1) 104667957(HS3ST3B1)
RBB: 
CJC: 
100413776(HS3ST3B1) 100414502(HS3ST3A1)
SBQ: 
MMU: 
15478(Hs3st3a1) 54710(Hs3st3b1)
RNO: 
303218(Hs3st3b1) 363618(Hs3st3a1)
CGE: 
NGI: 
103752044(Hs3st3b1) 103752048(Hs3st3a1)
HGL: 
101696746(Hs3st3b1)
CCAN: 
OCU: 
100352865(HS3ST3B1) 100355575(HS3ST3A1)
TUP: 
102487594(HS3ST3A1) 102489387(HS3ST3B1)
CFA: 
489512(HS3ST3A1) 489516(HS3ST3B1)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
106989807(HS3ST3A1)
BTA: 
521959(HS3ST3A1) 617069(HS3ST3B1)
BOM: 
102264332(HS3ST3A1) 102264905(HS3ST3B1)
BIU: 
109574448(HS3ST3B1) 109574478(HS3ST3A1)
PHD: 
102326770(HS3ST3B1) 102334005(HS3ST3A1)
CHX: 
102176640(HS3ST3A1) 102184089(HS3ST3B1)
OAS: 
101105173(HS3ST3A1) 101115554(HS3ST3B1)
SSC: 
100625836(HS3ST3A1) 100737777(HS3ST3B1)
CFR: 
102512802(HS3ST3A1)
CDK: 
BACU: 
103016406(HS3ST3A1)
LVE: 
103071775(HS3ST3A1) 103072323(HS3ST3B1) 103080038
ECB: 
100063069(HS3ST3B1) 100073112(HS3ST3A1)
EPZ: 
EAI: 
106845777(HS3ST3A1) 106845781(HS3ST3B1)
MYB: 
102261026(HS3ST3B1) 102261616(HS3ST3A1)
MYD: 
HAI: 
RSS: 
PALE: 
102889218(HS3ST3A1) 102889972(HS3ST3B1)
LAV: 
100667730(HS3ST3A1) 100668015(HS3ST3B1)
OAA: 
GGA: 
769421 769490(HS3ST3A1)
MGP: 
100547284(HS3ST3B1)
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
102104421(HS3ST3B1) 102112304(HS3ST3A1)
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
PSS: 
CMY: 
CPIC: 
101934697(HS3ST3A1) 101934991(HS3ST3B1)
ACS: 
PBI: 
GJA: 
XLA: 
XTR: 
100380167(hs3st3a1)
NPR: 
DRE: 
100329339(si:ch211-216b21.2) 558084(hs3st3b1b)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
102359925(HS3ST3B1) 102360615(HS3ST3A1)
CMK: 
BFO: 
SKO: 
DME: 
Dmel_CG7890(Hs3st-B)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD24871(Dsim_GD24871)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413133(Hs3st-B)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
PHU: 
ISC: 
CEL: 
CELE_F52B10.2(hst-3.2)
CBR: 
NAI: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
AQU: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:10608887]
  Authors
Liu J, Shriver Z, Blaiklock P, Yoshida K, Sasisekharan R, Rosenberg RD.
  Title
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues.
  Journal
J. Biol. Chem. 274 (1999) 38155-62.
  Sequence
[hsa:9955]
Reference
2  [PMID:10520990]
  Authors
Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG.
  Title
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.
  Journal
Cell. 99 (1999) 13-22.
  Sequence
[hsa:9955 9953][mmu:54710]
Reference
3  [PMID:9988767]
  Authors
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.
  Title
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
  Journal
J. Biol. Chem. 274 (1999) 5170-84.
  Sequence
[hsa:9955 9953]
Reference
4  [PMID:9988768]
  Authors
Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD.
  Title
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.
  Journal
J. Biol. Chem. 274 (1999) 5185-92.
  Sequence
[hsa:9955 9953]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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