| Entry |
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| Name |
petromyzonol sulfotransferase;
PZ-SULT
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| Class |
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
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| Sysname |
3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase
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| Reaction(IUBMB) |
3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate [RN: R07797]
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| Reaction(KEGG) |
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| Substrate |
3'-phosphoadenylyl sulfate [CPD: C00053];
5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol [CPD: C16258]
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| Product |
adenosine 3',5'-bisphosphate [CPD: C00054];
5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate [CPD: C16259]
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| Comment |
The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5alpha-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.
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| Reference |
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| Authors |
Venkatachalam KV, Llanos DE, Karami KJ, Malinovskii VA. |
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| Title |
Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver. |
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| Journal |
J. Lipid. Res. 45 (2004) 486-95. |
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| Organism |
Petromyzon marinus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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