KEGG   ENZYME: 2.8.2.32Help
Entry
EC 2.8.2.32                 Enzyme                                 

Name
scymnol sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl sulfate:5beta-scymnol sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate [RN:R07798]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
5beta-scymnol [CPD:C16260]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
5beta-scymnol sulfate [CPD:C16261]
Comment
The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5beta-scymnol (the natural bile salt) and 5alpha-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5beta-scymnol sulfate.
History
EC 2.8.2.32 created 2005
Reference
1  [PMID:7749614]
  Authors
Macrides TA, Faktor DA, Kalafatis N, Amiet RG.
  Title
Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol.
  Journal
Comp. Biochem. Physiol. Biochem. Mol. Biol. 107 (1994) 461-9.
Reference
2
  Authors
Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.
  Title
Investigation of 5beta-scymnol sulfotransferase from the kidney and testes of Heterodontus portusjacksoni.
  Journal
Comp. Biochem. Physiol. 121 (1998) 243-249.
Reference
3
  Authors
Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.
  Title
5beta-Scymnol sulfotransferase isolated from the tissues of an Australian shark species.
  Journal
Comp. Biochem. Physiol. 121 (1998) 299-307.
Reference
4
  Authors
Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.
  Title
5beta-scymnol sulfotransferase isolated from the liver of two Australian ray species.
  Journal
Comp. Biochem. Physiol. 121 (1998) 341-348.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
220581-70-4

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