KEGG   ENZYME: 2.8.2.34Help
Entry
EC 2.8.2.34                 Enzyme                                 

Name
glycochenodeoxycholate sulfotransferase;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile acid:PAPS:sulfotransferase;
BAST
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate [RN:R07289]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
glycochenodeoxycholate [CPD:C05466]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
glycochenodeoxycholate 7-sulfate [CPD:C15559]
Comment
The enzyme specifically sulfates glycochenodeoxycholate at the 7alpha-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.
History
EC 2.8.2.34 created 2005
Reference
1  [PMID:533830]
  Authors
Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI.
  Title
Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters.
  Journal
J. Lipid. Res. 20 (1979) 952-9.
Reference
2  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu. Rev. Biochem. 72 (2003) 137-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72668-90-7

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