KEGG   ENZYME: 2.8.2.35Help
Entry
EC 2.8.2.35                 Enzyme                                 

Name
dermatan 4-sulfotransferase;
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase;
dermatan-4-sulfotransferase-1;
dermatan-4-sulfotransferase 1;
D4ST-1;
dermatan N-acetylgalactosamine 4-O-sulfotransferase;
CHST14 protein;
CHST14
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase
Reaction(IUBMB)
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine [RN:R10873]
Reaction(KEGG)
Substrate
3'-phospho-5'-adenylyl sulfate [CPD:C00053];
[dermatan]-N-acetyl-D-galactosamine
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
Comment
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].
History
EC 2.8.2.35 created 2010
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K08105  
dermatan 4-sulfotransferase 1
Genes
HSA: 
113189(CHST14)
PTR: 
453336(CHST14)
PPS: 
100974168(CHST14)
GGO: 
101144190(CHST14)
PON: 
100460562(CHST14)
NLE: 
100582723(CHST14)
MCC: 
703115(CHST14)
MCF: 
102144190(CHST14)
RRO: 
104659660(CHST14)
CJC: 
100414908(CHST14)
MMU: 
72136(Chst14)
RNO: 
691394(Chst14)
CGE: 
NGI: 
103744909(Chst14)
HGL: 
101712567(Chst14)
OCU: 
100347170(CHST14)
TUP: 
102491092(CHST14)
CFA: 
608435(CHST14)
AML: 
100474523(CHST14)
UMR: 
103673547(CHST14)
FCA: 
101089445(CHST14)
PTG: 
102960344(CHST14)
BTA: 
511245(CHST14)
BOM: 
102276696(CHST14)
PHD: 
102321309(CHST14)
CHX: 
102171342(CHST14)
OAS: 
101108574(CHST14)
SSC: 
100520059(CHST14)
CFR: 
102522609(CHST14)
BACU: 
103015208(CHST14)
LVE: 
103077004(CHST14)
ECB: 
100146378(CHST14)
MYB: 
102255542(CHST14)
MYD: 
102756367(CHST14)
PALE: 
102895029(CHST14)
MDO: 
100027325(CHST14)
SHR: 
100925127(CHST14)
GGA: 
770193(CHST14)
MGP: 
104910967(CHST14)
CJO: 
107314214(CHST14)
APLA: 
101789722(CHST14)
GFR: 
102033127(CHST14)
FAB: 
101817927(CHST14)
PHI: 
102102390(CHST14)
CCW: 
104693010(CHST14)
FPG: 
101924189(CHST14)
FCH: 
102048313(CHST14)
CLV: 
102086987(CHST14)
AAM: 
106486718(CHST14)
ASN: 
102382545(CHST14)
AMJ: 
102567038(CHST14)
PSS: 
102462445(CHST14)
CMY: 
102945000(CHST14)
ACS: 
100563611(chst14)
PBI: 
103049955(CHST14)
GJA: 
107113505(CHST14)
XTR: 
100496179(chst14)
DRE: 
404732(chst14)
TRU: 
101073313(chst14)
MZE: 
101475363(chst14)
OLA: 
101163891(chst14)
XMA: 
102234472(chst14)
LCM: 
102352110(CHST14)
CMK: 
103178176(chst14)
BFO: 
CIN: 
SPU: 
SKO: 
NVE: 
AQU: 
CCP: 
AAF: 
 » show all
Taxonomy
Reference
1  [PMID:11470797]
  Authors
Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU
  Title
Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
  Journal
J. Biol. Chem. 276 (2001) 36344-53.
  Sequence
[hsa:113189]
Reference
2  [PMID:12847091]
  Authors
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K
  Title
Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine  4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
  Journal
J. Biol. Chem. 278 (2003) 36115-27.
  Sequence
[hsa:113189]
Reference
3  [PMID:19661164]
  Authors
Pacheco B, Maccarana M, Malmstrom A
  Title
Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.
  Journal
Glycobiology. 19 (2009) 1197-203.
  Sequence
[hsa:113189]
Reference
4  [PMID:16702220]
  Authors
Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K
  Title
Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.
  Journal
J. Biol. Chem. 281 (2006) 18942-52.
  Sequence
[mmu:72136]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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