KEGG   ENZYME: 2.8.2.36Help
Entry
EC 2.8.2.36                 Enzyme                                 

Name
desulfo-A47934 sulfotransferase;
StaL
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3',5'-bisphosphate + A47934 [RN:R10655]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
desulfo-A47934 [CPD:C20759]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
A47934 [CPD:C12016]
Comment
The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group.
History
EC 2.8.2.36 created 2014
Reference
1  [PMID:16492565]
  Authors
Lamb SS, Patel T, Koteva KP, Wright GD
  Title
Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.
  Journal
Chem. Biol. 13 (2006) 171-81.
  Sequence
Reference
2  [PMID:17329243]
  Authors
Shi R, Lamb SS, Bhat S, Sulea T, Wright GD, Matte A, Cygler M
  Title
Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis.
  Journal
J. Biol. Chem. 282 (2007) 13073-86.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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