| Entry |
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| Name |
desulfo-A47934 sulfotransferase;
StaL
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| Class |
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
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| Sysname |
3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase
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| Reaction(IUBMB) |
3'-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3',5'-bisphosphate + A47934 [RN: R10655]
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| Reaction(KEGG) |
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| Substrate |
3'-phosphoadenylyl sulfate [CPD: C00053];
desulfo-A47934 [CPD: C20759]
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| Product |
adenosine 3',5'-bisphosphate [CPD: C00054];
A47934 [CPD: C12016]
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| Comment |
The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group.
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| History |
EC 2.8.2.36 created 2014
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| Orthology |
| desulfo-A47934 sulfotransferase |
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| Reference |
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| Authors |
Lamb SS, Patel T, Koteva KP, Wright GD |
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| Title |
Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. |
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| Journal |
Chem. Biol. 13 (2006) 171-81. |
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| Sequence |
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| Reference |
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| Authors |
Shi R, Lamb SS, Bhat S, Sulea T, Wright GD, Matte A, Cygler M |
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| Title |
Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. |
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| Journal |
J. Biol. Chem. 282 (2007) 13073-86. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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