KEGG   ENZYME: 2.8.2.5Help
Entry
EC 2.8.2.5                  Enzyme                                 
Name
chondroitin 4-sulfotransferase;
chondroitin sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate [RN:R02180]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 4'-sulfate [CPD:C00634]
Comment
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Sulfur metabolism
Orthology
K01017  
chondroitin 4-sulfotransferase 11
K04742  
chondroitin 4-sulfotransferase 12
K07779  
chondroitin 4-sulfotransferase 13
Genes
HSA: 
166012(CHST13) 50515(CHST11) 55501(CHST12)
PTR: 
467113(CHST11) 471065(CHST13) 472270(CHST12)
PPS: 
100971795(CHST13) 100975988(CHST11) 100977359(CHST12)
GGO: 
101133837(CHST11) 101139277(CHST13) 101144960(CHST12)
PON: 
100441016(CHST13) 100456373(CHST12) 100457862(CHST11)
MCC: 
700690(CHST11) 713591(CHST12) 716548(CHST13)
MMU: 
58250(Chst11) 59031(Chst12) 71797(Chst13)
RNO: 
304322(Chst12) 314694(Chst11) 500257(Chst13)
CFA: 
481299(CHST11) 484618(CHST13) 609635(CHST12)
AML: 
FCA: 
101085731(CHST11) 101086274(CHST12) 101093089(CHST13)
BTA: 
513030(CHST12) 523460(CHST13) 528860(CHST11)
SSC: 
100157186 100519444 100524793
ECB: 
100059762 100067989(CHST11)
MDO: 
100010103 100015110(CHST11) 100026788
SHR: 
100914185(CHST12) 100921711(CHST11)
OAA: 
100076609(CHST11) 100082901 100088952
GGA: 
416032(CHST13) 416469(CHST12) 418081(CHST11)
MGP: 
100543037 100548662
TGU: 
100222220(CHST12) 100225306(CHST11) 100228818
ACS: 
100551540(chst11) 100566390
XLA: 
380581(chst11) 496355(chst12) 734260(chst13)
XTR: 
100125190(chst11) 493458(chst13) 548703(chst12)
DRE: 
404232(chst11) 407076(chst12a) 565671(wu:fb44a12)
TRU: 
101072910 101077961
OLA: 
101165116 101170346
BFO: 
BRAFLDRAFT_66516
SPU: 
591353
DAN: 
Dana_GF14777
DPE: 
Dper_GL14199
DSE: 
Dsec_GM17218
DWI: 
Dwil_GK18242
DYA: 
Dyak_GE12777
DGR: 
Dgri_GH13107
DMO: 
Dmoj_GI22530
DVI: 
Dvir_GJ23046
AGA: 
AgaP_AGAP004371
AAG: 
AaeL_AAEL000716
AME: 
550998
NVI: 
100119726(NV15280)
TCA: 
663404
API: 
100160220
PHU: 
Phum_PHUM310380
NVE: 
NEMVE_v1g93663
HMG: 
100204866
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim. Biophys. Acta. 717 (1982) 414-21.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:6130977]
  Authors
Nakanishi Y, Otsu K, Suzuki S.
  Title
Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine.
  Journal
FEBS. Lett. 151 (1983) 15-8.
  Organism
Gallus gallus [GN:gga]
Reference
3  [PMID:6787041]
  Authors
Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S.
  Title
A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate.
  Journal
J. Biol. Chem. 256 (1981) 5443-9.
  Organism
Gallus gallus [GN:gga]
Reference
4  [PMID:13835879]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides.
  Journal
J. Biol. Chem. 235 (1960) 257-66.
  Organism
Gallus gallus [GN:gga]
Reference
5  [PMID:13835880]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors.
  Journal
J. Biol. Chem. 235 (1960) 267-73.
  Organism
Gallus gallus [GN:gga]
Reference
6  [PMID:13835881]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondrotin and chondrotin sulfate A.
  Journal
J. Biol. Chem. 235 (1960) 274-6.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83589-04-2
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