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Entry
EC 2.8.2.5                  Enzyme                                 

Name
chondroitin 4-sulfotransferase;
chondroitin sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate [RN:R02180]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 4'-sulfate [CPD:C00634]
Comment
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
History
EC 2.8.2.5 created 1965, modified 1986
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K01017  chondroitin 4-sulfotransferase 11
K04742  chondroitin 4-sulfotransferase 12
K07779  chondroitin 4-sulfotransferase 13
Genes
HSA: 166012(CHST13) 50515(CHST11) 55501(CHST12)
PTR: 467113(CHST11) 471065(CHST13) 472270(CHST12)
PPS: 100971795(CHST13) 100975988(CHST11) 100977359(CHST12)
GGO: 101133837 101139277(CHST13) 101144960(CHST12) 109029234(CHST11)
PON: 100456373(CHST12) 100457862(CHST11) 103890079(CHST13)
NLE: 100589808(CHST12) 100594174(CHST13) 100602866(CHST11)
MCC: 700690(CHST11) 713591(CHST12) 716548(CHST13)
MCF: 102121463(CHST12) 102142576(CHST13) 102145281(CHST11)
CSAB: 103228121(CHST13) 103238996(CHST11) 103246866(CHST12)
RRO: 104657479(CHST11) 104664960(CHST12) 104675913(CHST13)
RBB: 108528199(CHST13) 108543796(CHST12) 108544272(CHST11)
CJC: 100389849(CHST13) 100399023(CHST12) 100402381(CHST11)
SBQ: 101041861(CHST11) 101050645(CHST13) 101051059(CHST12)
MMU: 58250(Chst11) 59031(Chst12) 71797(Chst13)
RNO: 304322(Chst12) 314694(Chst11) 500257(Chst13)
CGE: 100762689(Chst12) 100771243(Chst13) 100771304(Chst11)
NGI: 103730362(Chst13) 103742136(Chst11) 103748676(Chst12)
HGL: 101699086(Chst11) 101700717(Chst12) 101703999(Chst13)
CCAN: 109675795(Chst11) 109694295(Chst12) 109700988(Chst13)
OCU: 100340729(CHST12) 100343641(CHST11) 100357997(CHST13)
TUP: 102472415(CHST12) 102500906(CHST11)
CFA: 481299(CHST11) 484618(CHST13) 609635(CHST12)
AML: 100475790(CHST11) 100478956(CHST12) 105239284(CHST13)
ORO: 101369477(CHST12) 101375725(CHST13) 101381523(CHST11)
FCA: 101085731(CHST11) 101086274(CHST12) 101093089(CHST13)
PTG: 102956639(CHST11) 102962488(CHST12)
AJU: 106971879(CHST11) 106984521(CHST12)
BTA: 513030(CHST12) 523460(CHST13) 528860(CHST11)
BOM: 102266002(CHST11) 102284925(CHST12)
BIU: 109556624(CHST13) 109559464(CHST11) 109578774(CHST12)
PHD: 102324187(CHST12) 102343636(CHST11)
CHX: 102168320(CHST12) 102184407(CHST11) 108633379(CHST13)
OAS: 101113667(CHST11) 101118845(CHST12)
SSC: 100157186(CHST11) 100519444(CHST13) 100524793(CHST12)
CFR: 102505142(CHST12) 102520253(CHST11) 106730843
CDK: 105097485(CHST11) 105105772(CHST12)
BACU: 103001272(CHST12) 103007407(CHST11) 103018950(CHST13)
LVE: 103068836(CHST13) 103088503(CHST11) 103089407(CHST12)
OOR: 101282560(CHST12) 101286427(CHST13) 101287126(CHST11)
ECB: 100059762(CHST12) 100067989(CHST11) 111768279(CHST13)
EPZ: 103551754(CHST12) 103554080(CHST11)
EAI: 106834774(CHST12) 106846795(CHST11)
MYB: 102256866(CHST11) 102261451(CHST12)
MYD: 102763992(CHST11) 102765213(CHST12)
HAI: 109376608(CHST13) 109380237(CHST12) 109387746(CHST11)
RSS: 109439260(CHST13) 109445796(CHST11) 109461373(CHST12)
PALE: 102887006(CHST11) 102893899(CHST13) 102897939(CHST12)
LAV: 100669843(CHST13) 100672295(CHST11) 100675592(CHST12)
MDO: 100010103(CHST12) 100015110(CHST11) 100026788(CHST13)
SHR: 100914185(CHST12) 100921711(CHST11) 100922364(CHST13)
OAA: 100076609(CHST11) 100082901(CHST12) 100088952
GGA: 416032(CHST13) 416469(CHST12) 418081(CHST11)
MGP: 100540137(CHST13) 100543037(CHST11) 100548662(CHST12)
CJO: 107314821(CHST11) 107319851(CHST13) 107320779(CHST12)
APLA: 101793228(CHST13) 101796810(CHST12) 101802330(CHST11)
ACYG: 106033547(CHST12) 106035913(CHST11) 106045054(CHST13)
TGU: 100222220(CHST12) 100225306(CHST11) 100228818(CHST13)
GFR: 102034597(CHST11) 102042843(CHST13) 102042953(CHST12)
FAB: 101806996(CHST11) 101808164(CHST13) 101816778(CHST12)
PHI: 102103855(CHST12) 102109237(CHST13) 102110718(CHST11)
PMAJ: 107205092(CHST11) 107210495(CHST13) 107210929(CHST12)
CCW: 104683299(CHST13) 104684815(CHST12) 104696241(CHST11)
FPG: 101910612(CHST12) 101914956(CHST13) 101924047(CHST11)
FCH: 102046810(CHST11) 102058463(CHST13) 102058489(CHST12)
CLV: 102088065(CHST13) 102089116(CHST12) 102095894(CHST11)
EGZ: 104126707(CHST13) 104132591(CHST12) 104132737(CHST11)
AAM: 106488448(CHST11) 106498985(CHST13) 106499955(CHST12)
ASN: 102379722(CHST12) 102383336(CHST13) 102384031(CHST11)
AMJ: 102564297(CHST11) 102565939(CHST12) 102574132(CHST13)
PSS: 102449023(CHST11) 102459582(CHST13) 102463513(CHST12)
CMY: 102932531(CHST12) 102941104 102942919(CHST11)
CPIC: 101937092(CHST11) 101944705(CHST13) 101953300(CHST12)
ACS: 100551540(chst11) 100560568(chst13) 100566390(chst12)
PVT: 110084788(CHST11) 110091163 110091687(CHST12)
PBI: 103048906(CHST11) 103049785(CHST12) 103049881
GJA: 107112011(CHST12) 107124190(CHST11) 107125909(CHST13)
XLA: 108703125(chst12.S) 108711031 108713201 380581(chst13.L) 496355(chst12.L) 734260(chst13.S)
XTR: 100125190(chst11) 493458(chst13) 548703(chst12)
NPR: 108784926(CHST11) 108786200(CHST12) 108802185
DRE: 404232(chst11) 407076(chst12a) 565671(si:ch211-236h17.3)
XMA: 102224428(chst12) 102229515 102235302 102236173(chst11)
BPEC: 110157995 110159100(chst11) 110162319(chst12) 110165816
SFM: 108918170 108920743(chst11) 108922503(chst12) 108939113
LCM: 102347601(CHST12) 102350815(CHST11) 102354698(CHST13) 102365200
CMK: 103175681 103176680(chst13) 103179823(chst11) 103186616 103186826(chst12)
SPU: 591353
DME: Dmel_CG31743(CG31743)
DSI: Dsimw501_GD24092(Dsim_GD24092)
MDE: 101899240
AAG: 5565900
AME: 100576099 550998(GB10157)
PBAR: 105427651
NVI: 100119726
TCA: 663404
DPA: 109546811
NVL: 108561330
API: 100160220
DNX: 107168413
FCD: 110841711
HMG: 100204866
AQU: 105313833
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim. Biophys. Acta. 717 (1982) 414-21.
Reference
2  [PMID:6130977]
  Authors
Nakanishi Y, Otsu K, Suzuki S.
  Title
Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine.
  Journal
FEBS. Lett. 151 (1983) 15-8.
Reference
3  [PMID:6787041]
  Authors
Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S.
  Title
A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate.
  Journal
J. Biol. Chem. 256 (1981) 5443-9.
Reference
4  [PMID:13835879]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides.
  Journal
J. Biol. Chem. 235 (1960) 257-66.
Reference
5  [PMID:13835880]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors.
  Journal
J. Biol. Chem. 235 (1960) 267-73.
Reference
6  [PMID:13835881]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondrotin and chondrotin sulfate A.
  Journal
J. Biol. Chem. 235 (1960) 274-6.
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.5
IUBMB Enzyme Nomenclature: 2.8.2.5
ExPASy - ENZYME nomenclature database: 2.8.2.5
BRENDA, the Enzyme Database: 2.8.2.5
CAS: 83589-04-2

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