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Entry
EC 2.8.3.21                 Enzyme                                 

Name
L-carnitine CoA-transferase;
CaiB;
crotonobetainyl/gamma-butyrobetainyl-CoA:carnitine CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
(E)-4-(trimethylammonio)but-2-enoyl-CoA:L-carnitine CoA-transferase
Reaction(IUBMB)
(1) (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA [RN:R10643];
(2) 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA [RN:R10644]
Reaction(KEGG)
Substrate
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:C20748];
L-carnitine [CPD:C00318];
4-trimethylammoniobutanoyl-CoA [CPD:C20749]
Product
(E)-4-(trimethylammonio)but-2-enoate [CPD:C04114];
L-carnitinyl-CoA [CPD:C20750];
4-trimethylammoniobutanoate [CPD:C01181]
Comment
The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. It has similar activity with both substrates.
History
EC 2.8.3.21 created 2014
Orthology
K08298  
L-carnitine CoA-transferase
Genes
ECO: 
b0038(caiB)
ECJ: 
JW0037(caiB)
ECD: 
EBW: 
BWG_0036(caiB)
ECOK: 
ECE: 
Z0044(caiB)
ECS: 
ECF: 
ETW: 
ECSP_0041(caiB)
ELX: 
EOJ: 
EOI: 
EOH: 
ECG: 
EOK: 
ELR: 
ECC: 
c0047(caiB)
ECP: 
ECI: 
ECV: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_0039(caiB)
EUM: 
ECZ: 
ELO: 
ELN: 
ELH: 
ESE: 
ESO: 
ESM: 
ESL: 
ECL: 
EKO: 
EKF: 
EAB: 
EDH: 
EDJ: 
EIH: 
ENA: 
ELU: 
EUN: 
ELW: 
ECW_m0038(caiB)
ELL: 
WFL_00190(caiB)
ELC: 
i14_0040(caiB)
ELD: 
i02_0040(caiB)
ELP: 
ELF: 
LF82_0258(caiB)
ECOA: 
ECOL: 
ECOI: 
ECOJ: 
ECOO: 
ECOH: 
ECOS: 
EFE: 
EFER_0046(caiB)
EAL: 
STY: 
STY0082(caiB)
STT: 
t0073(caiB)
SEX: 
SENT: 
STM: 
STM0072(caiB)
SEO: 
SEV: 
SEM: 
SEJ: 
SEF: 
SETU: 
SETC: 
SENR: 
SEND: 
SENI: 
SEEN: 
SPT: 
SPA0073(caiB)
SEK: 
SPQ: 
SEI: 
SPC_0077(caiB)
SEC: 
SCH_0066(caiB)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SEG: 
SG0075(caiB)
SEL: 
SPUL_0077(caiB)
SEGA: 
SET: 
SEN0073(caiB)
SENA: 
SENO: 
SENV: 
SENQ: 
SENL: 
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
BN855_750(caiB)
SENE: 
SENC: 
SES: 
SBG: 
SBG_0057(caiB)
SBZ: 
SBV: 
SFL: 
SF0035(caiB)
SFX: 
S0037(caiB)
SFV: 
SFV_0032(caiB)
SFE: 
SFxv_0036(caiB)
SFN: 
SFS: 
SFT: 
SSJ: 
SDY: 
SDY_0060(caiB)
SDZ: 
ESC: 
KLE: 
CKO: 
CRO: 
ROD_00401(caiB)
CFD: 
CAMA: 
CIF: 
EBT: 
KIN: 
EBF: 
PMR: 
PMI2656(caiB)
PMIB: 
PVL: 
EIC: 
ETR: 
ETAE_2662(caiB)
ETD: 
ETE: 
ETC: 
EDW: 
EDL: 
EHO: 
HAV: 
OPO: 
SLO: 
SSE: 
SPL: 
SHL: 
SWP: 
BACI: 
DSY: 
DHD: 
DDH: 
DMT: 
DRM: 
GOR: 
PFR: 
PFRE: 
AHE: 
TPY: 
TPYO: 
AMY: 
ELE: 
EYY: 
EGYY_03120(CaiB) EGYY_03150(CaiB) EGYY_17900(CaiB) EGYY_17980(CaiB) EGYY_27330(CaiB) EGYY_27410(CaiB)
GPA: 
CBAC: 
 » show all
Taxonomy
Reference
1  [PMID:11409545]
  Authors
Engemann C, Elssner T, Kleber HP.
  Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
  Journal
Arch. Microbiol. 175 (2001) 353-9.
  Sequence
[ag:CAD48580] [pmib:BB2000_2647] [pmr:PMI2656]
Reference
2  [PMID:11551212]
  Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
  Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and  a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
  Journal
Biochemistry. 40 (2001) 11140-8.
  Sequence
[eco:b0038]
Reference
3  [PMID:15518548]
  Authors
Stenmark P, Gurmu D, Nordlund P
  Title
Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism.
  Journal
Biochemistry. 43 (2004) 13996-4003.
  Sequence
[eco:b0038]
Reference
4  [PMID:15731894]
  Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
  Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
  Journal
Arch. Microbiol. 183 (2005) 176-89.
  Sequence
[ag:CAD48580] [pmib:BB2000_2647] [pmr:PMI2656]
Reference
5  [PMID:15823031]
  Authors
Rangarajan ES, Li Y, Iannuzzi P, Cygler M, Matte A
  Title
Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA.
  Journal
Biochemistry. 44 (2005) 5728-38.
  Sequence
[eco:b0038]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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