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Entry
EC 2.8.3.22                 Enzyme                                 

Name
succinyl-CoA---L-malate CoA-transferase;
SmtAB
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
succinyl-CoA:(S)-malate CoA-transferase
Reaction(IUBMB)
(1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA [RN:R00406];
(2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA [RN:R03154]
Reaction(KEGG)
Substrate
succinyl-CoA [CPD:C00091];
(S)-malate [CPD:C00149];
(S)-citramalate [CPD:C02614]
Product
succinate [CPD:C00042];
(S)-malyl-CoA [CPD:C04348];
(S)-citramalyl-CoA [CPD:C01011]
Comment
The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 2.8.3.22 created 2014
Pathway
C5-Branched dibasic acid metabolism
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14471  
succinyl-CoA:(S)-malate CoA-transferase subunit A
K14472  
succinyl-CoA:(S)-malate CoA-transferase subunit B
K18289  
itaconate CoA-transferase
Genes
PAE: 
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PMK: 
PPSE: 
PCQ: 
PPW: 
PPUN: 
PFV: 
PSB: 
PFL: 
PPRC: 
PPRO: 
PFS: 
PFC: 
PFW: 
PFB: 
PFF: 
PFX: 
PSA: 
PSZ: 
PSR: 
PSC: 
PSJ: 
PSH: 
PSTU: 
PSTT: 
PBM: 
PPUU: 
PDR: 
PSK: 
PCH: 
PCZ: 
PCP: 
PRH: 
PPV: 
PSES: 
PSEM: 
PKR: 
MARI: 
ADI: 
APAC: 
AXE: 
RPJ: 
CNC: 
BPA: 
BBR: 
BBM: 
BBH: 
BBX: 
BPT: 
BHO: 
BHM: 
BHZ: 
BTRM: 
AXY: 
AXO: 
AXN: 
AXS: 
AXX: 
ADT: 
AIS: 
TEQ: 
TEA: 
TEG: 
TAS: 
TAT: 
PUT: 
AKA: 
AMIM: 
HHT: 
APP: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CCOO: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
 » show all
Taxonomy
Reference
1  [PMID:16547052]
  Authors
Friedmann S, Steindorf A, Alber BE, Fuchs G.
  Title
Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J. Bacteriol. 188 (2006) 2646-55.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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