KEGG   ENZYME: 3.1.1.28Help
Entry
EC 3.1.1.28                 Enzyme                                 

Name
acylcarnitine hydrolase;
high activity acylcarnitine hydrolase;
HACH;
carnitine ester hydrolase;
palmitoylcarnitine hydrolase;
palmitoyl-L-carnitine hydrolase;
long-chain acyl-L-carnitine hydrolase;
palmitoyl carnitine hydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
O-acylcarnitine acylhydrolase
Reaction(IUBMB)
O-acylcarnitine + H2O = a fatty acid + L-carnitine [RN:R01924]
Reaction(KEGG)
Substrate
O-acylcarnitine [CPD:C02301];
H2O [CPD:C00001]
Product
fatty acid [CPD:C00162];
L-carnitine [CPD:C00318]
Comment
Acts on higher fatty acid (C6 to C18) esters of L-carnitine; highest activity is with O-decanoyl-L-carnitine.
History
EC 3.1.1.28 created 1972
Reference
1  [PMID:5806585]
  Authors
Mahadevan S, Sauer F.
  Title
Carnitine ester hydrolase of rat liver.
  Journal
J. Biol. Chem. 244 (1969) 4448-53.
  Organism
Rattus norvegicus
Reference
2  [PMID:4026306]
  Authors
Mentlein R, Reuter G, Heymann E.
  Title
Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function.
  Journal
Arch. Biochem. Biophys. 240 (1985) 801-10.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37278-42-5

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