KEGG   ENZYME: 3.1.1.45Help
Entry
EC 3.1.1.45                 Enzyme                                 
Name carboxymethylenebutenolidase;
maleylacetate enol-lactonase;
dienelactone hydrolase;
carboxymethylene butenolide hydrolase
Class Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname 4-carboxymethylenebut-2-en-4-olide lactonohydrolase
Reaction(IUBMB) 4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate
[RN:R03893]
Reaction(KEGG) R03893;
(other) R05510 R05511 R06835 R06838 R08120 R08121
Show
Substrate 4-carboxymethylenebut-2-en-4-olide [CPD:C04431];
H2O [CPD:C00001]
Product 4-oxohex-2-enedioate [CPD:C02222]
Pathway PATH: ec00361  gamma-Hexachlorocyclohexane degradation
PATH: ec00364  Fluorobenzoate degradation
PATH: ec00627  1,4-Dichlorobenzene degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K01061  carboxymethylenebutenolidase
Genes HSA: 134147(CMBL)
MCC: 696762
RNO: 310201(Cmbl)
CFA: 478619(CMBL)
NVE: NEMVE_v1g164392
ATH: AT2G32520
POP: POPTR_1108355 POPTR_732264
RCU: RCOM_1226380 RCOM_2119700
OSA: 4327800(Os01g0531500)
SBI: SORBI_03g023240(SORBIDRAFT_03g023240)
ZMA: 100282241(pco117250)
PPP: PHYPADRAFT_67702
CRE: CHLREDRAFT_142342 CHLREDRAFT_172688
OLU: OSTLU_39889
SCE: YDL086W
AGO: AGOS_ADR265C
KLA: KLLA0F07381g
LTH: KLTH0H15774g
DHA: DEHA0D08602g
PIC: PICST_78962(DLH1)
VPO: Kpol_1058p55
LEL: LELG_01520
ZRO: ZYRO0A08162g
CTP: CTRG_04677
CDU: CD36_02580
CGR: CAGL0L06974g
YLI: YALI0C20625g
NCR: NCU09600 NCU09656
PAN: PODANSg300 PODANSg6942
MGR: MGG_02465 MGG_02570 MGG_06957 MGG_09427
FGR: FG00832.1 FG02819.1
ANI: AN5184.2 AN5376.2
AFM: AFUA_1G07130 AFUA_6G13900
AOR: AO090012000964 AO090038000051
ANG: An08g08300 An12g06540
AFV: AFLA_125180 AFLA_125470
PCS: Pc22g00580 Pc22g11550
NFI: NFIA_017590 NFIA_059870
CIM: CIMG_02465 CIMG_05574
URE: UREG_03246 UREG_06164
SSL: SS1G_05962 SS1G_11462
BFU: BC1G_08937 BC1G_15184
CNE: CNA06410
CNB: CNBA6220
LBC: LACBIDRAFT_186973
UMA: UM01170.1
TET: TTHERM_00594110 TTHERM_00616010
PTM: GSPATT00024881001 GSPATT00024882001 GSPATT00034164001
ECO: b3830(ysgA)
ECJ: JW5853(ysgA)
ECD: ECDH10B_4021(ysgA)
EBW: BWG_3508(ysgA)
ECE: Z4353 Z5352
ECS: ECs3884 ECs4760
ECF: ECH74115_4312 ECH74115_5271
ETW: ECSP_3978(yghX) ECSP_4885(ysgA)
ECG: E2348C_3286(yghX) E2348C_4144(ysgA)
ECC: c3736 c4771
ECI: UTI89_C3421 UTI89_C4410
ECP: ECP_3085 ECP_4039
ECV: APECO1_2631 APECO1_3423
ECW: EcE24377A_3469 EcE24377A_4351
ECX: EcHS_A4054
ECM: EcSMS35_3286 EcSMS35_4206
ECY: ECSE_3284 ECSE_4118
ECL: EcolC_4178
ECK: EC55989_3417 EC55989_4307(ysgA)
ECQ: ECED1_3650 ECED1_4527(ysgA)
ECR: ECIAI1_3149 ECIAI1_4025(ysgA)
ECT: ECIAI39_3172(ysgA) ECIAI39_3496
ECZ: ECS88_3382 ECS88_4274(ysgA)
EUM: ECUMN_3484 ECUMN_4356(ysgA)
ELF: LF82_3211(yghX) LF82_3701(ysgA)
EBL: B21_02824(yghX) B21_03666(ysgA)
EBD: ECBD_0738 ECBD_4199
EBR: ECB_02875(yghXY) ECB_03717(ysgA)
EOH: ECO103_3684(yghX) ECO103_4333(ysgA)
EOI: ECO111_3829(yghX) ECO111_4658(ysgA)
EOJ: ECO26_4107(yghX) ECO26_4755(ysgA)
EFE: EFER_2942 EFER_3656(ysgA)
STY: STY3592(ysgA)
STT: t3330(ysgA)
SPT: SPA3808(ysgA)
SEK: SSPA3546
SPQ: SPAB_04923
SEI: SPC_4075(ysgA)
SEC: SC3865(dlhH)
SEH: SeHA_C4294
SEE: SNSL254_A4247
SEW: SeSA_A4175
SEA: SeAg_B4198
SEG: SG3484(dlhH)
SET: SEN3762(dlhH)
SES: SARI_03690
STM: STM3967(dlhH)
YPE: YPO3787
YPK: y0443
YPM: YP_3262
YPA: YPA_0237
YPN: YPN_0177
YPG: YpAngola_A3647
YPP: YPDSF_3404
YPS: YPTB0249
YPI: YpsIP31758_0265
YPY: YPK_3951
YPB: YPTS_0265
YEN: YE0250
SFL: SF3046 SF3908
SFX: S3247
SFV: SFV_3052(yghYX) SFV_3668(ysgA)
SSN: SSON_3144(yghYX) SSON_4005(ysgA)
SBO: SBO_3844
SBC: SbBS512_E3428 SbBS512_E4302
SDY: SDY_3913
ECA: ECA0184
PCT: PC1_4070
PWA: Pecwa_4353
ETA: ETA_02320
ENT: Ent638_3409 Ent638_3963
ESA: ESA_03730
CTU: Ctu_02610(ysgA)
KPN: KPN_03421 KPN_04326(ysgA)
KPE: KPK_0697 KPK_5347
KPU: KP1_0188(ysgA) KP1_4697
CKO: CKO_00172 CKO_04395
SPE: Spro_0243
DDA: Dd703_0186
DDC: Dd586_0177
DZE: Dd1591_3933
XCC: XCC2566 XCC2737
XCB: XC_1376 XC_1552
XCA: xccb100_1595
XCV: XCV2888 XCV3051
XAC: XAC2736 XAC2907
XOO: XOO1437
XOM: XOO_1321 XOO_3099
XOP: PXO_01246
SML: Smlt3439(clcD)
SMT: Smal_2866
VVU: VV2_0395
VVY: VVA0953
VPA: VPA1061
VHA: VIBHAR_05585
VEX: VEA_001605
PAE: PA2682
PAU: PA14_29420(ysgA)
PAP: PSPA7_3956
PAG: PLES_24221
PPF: Pput_2906
PST: PSPTO_2806
PSB: Psyr_2534
PSP: PSPPH_2691
PFS: PFLU3464
PEN: PSEEN1342 PSEEN3627
PSA: PST_2945
CJA: CJA_1059 CJA_2039
AVN: Avin_19040 Avin_37970
ACI: ACIAD2677
ACB: A1S_1741
ABC: ACICU_01777
ABN: AB57_1970
ABB: ABBFA_001754
SON: SO_1006
SDN: Sden_3046
SAZ: Sama_0613
SBL: Sbal_3378
SBM: Shew185_0965 Shew185_3507
SBN: Sbal195_1000 Sbal195_3630
SBP: Sbal223_0985 Sbal223_3435
SPC: Sputcn32_3006
SSE: Ssed_0826
SPL: Spea_0743
SHE: Shewmr4_0806 Shewmr4_0833
SHM: Shewmr7_3190 Shewmr7_3217
SHN: Shewana3_3286 Shewana3_3320
SHW: Sputw3181_0943
SHL: Shal_0796
SWD: Swoo_0924
SWP: swp_4332
CPS: CPS_4005
PHA: PSHAa2188
PAT: Patl_0207 Patl_1546
LPN: lpg1635
LPF: lpl1391
LPP: lpp1605
LPC: LPC_1064
TGR: Tgr7_0666
HCH: HCH_00119
CSA: Csal_2697
MMW: Mmwyl1_2467 Mmwyl1_3288
TAU: Tola_1754
AFE: Lferr_1865
AFR: AFE_2210
CVI: CV_3204
RSO: RS04764(RSp1339) RSc2228
RPI: Rpic_2433 Rpic_4117
RPF: Rpic12D_2040 Rpic12D_4229
REU: Reut_A0875 Reut_A3180 Reut_B5577 Reut_B5771 Reut_C6316
     Reut_C6385 Reut_D6464 Reut_D6472
REH: H16_A2215 H16_A2739 H16_A3488 H16_B0175
RME: Rmet_2622 Rmet_3321 Rmet_3645
CTI: RALTA_A2242 RALTA_A2949 RALTA_B0183(clcD)
BMA: BMA2838 BMAA0324
BMV: BMASAVP1_1506 BMASAVP1_A3413
BML: BMA10229_1700 BMA10229_A1705
BMN: BMA10247_3138 BMA10247_A0358
BPS: BPSL3286 BPSS1767
BPM: BURPS1710b_0053 BURPS1710b_A0848
BPL: BURPS1106A_3915 BURPS1106A_A2398
BPD: BURPS668_3834 BURPS668_A2540
BPR: GBP346_A4020
BTE: BTH_I3160 BTH_II0609
BVI: Bcep1808_0236 Bcep1808_4251 Bcep1808_5490 Bcep1808_6461
BUR: Bcep18194_A3379 Bcep18194_B2216 Bcep18194_C6610 Bcep18194_C7069
     Bcep18194_C7177
BCN: Bcen_2831 Bcen_4491 Bcen_5485 Bcen_5840
BCH: Bcen2424_0276 Bcen2424_3874 Bcen2424_6207 Bcen2424_6771
BCM: Bcenmc03_0258 Bcenmc03_3653 Bcenmc03_6359 Bcenmc03_6683
BCJ: BCAL0149 BCAL1770 BCAM0906 BCAM2127 BCAS0317 BCAS0763
BAM: Bamb_0190 Bamb_3245 Bamb_5994 Bamb_6309
BAC: BamMC406_0203 BamMC406_3771 BamMC406_5750 BamMC406_6013
BMU: Bmul_0184 Bmul_4825 Bmul_5328
BMJ: BMULJ_03080 BMULJ_03691 BMULJ_05363
BXE: Bxe_A1127(clcD) Bxe_A3568 Bxe_A4330 Bxe_B0274 Bxe_B0548
     Bxe_B2832
BPH: Bphy_0111 Bphy_4061 Bphy_4421
BPY: Bphyt_0391 Bphyt_4121 Bphyt_6786 Bphyt_7160
BGL: bglu_1g02030 bglu_2g15990 bglu_2g20650
PNU: Pnuc_1276 Pnuc_1710
BPE: BP1256 BP2713
BPA: BPP1116 BPP1871 BPP2783
BBR: BB1332 BB2702 BB3237
BPT: Bpet0310 Bpet1537 Bpet3124 Bpet3735 Bpet3751
BAV: BAV2386(clcD)
RFR: Rfer_3313 Rfer_3810
POL: Bpro_0241 Bpro_1733 Bpro_2724
PNA: Pnap_0188 Pnap_2091
AAV: Aave_0321 Aave_1943
AJS: Ajs_0260 Ajs_3316
VEI: Veis_1220
DAC: Daci_0373 Daci_1793 Daci_5324
DIA: Dtpsy_0255 Dtpsy_2668
VAP: Vapar_1548 Vapar_4930 Vapar_5380 Vapar_5412
CTT: CtCNB1_0292 CtCNB1_0924
MPT: Mpe_A3005
HAR: HEAR0270
MMS: mma_0324
LCH: Lcho_0092 Lcho_2322 Lcho_3586 Lcho_4378
AZO: azo2340 azo2647(dlhH)
DAR: Daro_0181 Daro_3231
TMZ: Tmz1t_0774
MFA: Mfla_2602
MMB: Mmol_2306
MEI: Msip34_2756
APP: CAP2UW1_2839
GSU: GSU2536
BBA: Bd0982
DAT: HRM2_45330
AFW: Anae109_1616
MXA: MXAN_6883
SCL: sce0062(dlhH1) sce0098 sce0100 sce7034(dlhH2)
SAT: SYN_02346
MLO: mll1495
MES: Meso_1987
PLA: Plav_1266 Plav_2252
SME: SMc00817
SMD: Smed_0381
ATU: Atu0627(dlhH)
ATC: AGR_C_1114
ARA: Arad_2932 Arad_4085
AVI: Avi_5769(dlhH)
RET: RHE_PE00366(ype00187)
REC: RHECIAT_PA0000292
RLE: pRL110484
RLT: Rleg2_5691
RLG: Rleg_6635
RHI: NGR_c03800
OAN: Oant_3327
BJA: bll0837 bll6841
BRA: BRADO0895 BRADO1986 BRADO2952 BRADO3398 BRADO5403 BRADO7139
BBT: BBta_2303 BBta_4308 BBta_4503 BBta_5221 BBta_5888 BBta_7175
     BBta_7870
RPA: RPA1194 RPA4832(clcD)
RPB: RPB_1202
RPC: RPC_0926
RPD: RPD_1304
RPE: RPE_0950
RPT: Rpal_1386 Rpal_5319
OCA: OCAR_6994 OCAR_7059
XAU: Xaut_0137
AZC: AZC_0916 AZC_3434
MEX: Mext_1804
MEA: Mex_1p1735
MDI: METDI2487
MRD: Mrad2831_2733
MET: M446_2042
MPO: Mpop_1756
MCH: Mchl_2140
MNO: Mnod_1951
BID: Bind_0283
MSL: Msil_0943 Msil_3130
CCR: CC_2358 CC_3758
CCS: CCNA_00510 CCNA_00511 CCNA_02443 CCNA_03874
CAK: Caul_0145 Caul_0705 Caul_0706 Caul_5021
PZU: PHZ_c0272 PHZ_c2866 PHZ_c2867 PHZ_c3529(ysgA)
PDE: Pden_0735
MMR: Mmar10_2526
HBA: Hbal_2445
ZMO: ZMO1351 ZMO1992
ZMN: Za10_0006 Za10_1182
NAR: Saro_0139 Saro_2806
SAL: Sala_2285 Sala_2851
SWI: Swit_0846 Swit_2080 Swit_2842
ELI: ELI_13040
GOX: GOX1900
GBE: GbCGDNIH1_1367
ACR: Acry_0900 Acry_2181 Acry_2716
GDI: GDI_2054 GDI_3255
GDJ: Gdia_0275 Gdia_3109
APT: APA01_17850
RRU: Rru_A2775
RCE: RC1_1522 RC1_2805
MAG: amb4377
AAC: Aaci_2579
MTU: Rv2054 Rv2765
MTC: MT2114 MT2835
MRA: MRA_2069 MRA_2790
MTF: TBFG_12091 TBFG_12778
MTB: TBMG_01210(TBMG_01210.1) TBMG_01927(TBMG_01927.1)
MBO: Mb2080 Mb2787
MBB: BCG_2073 BCG_2782
MBT: JTY_2068 JTY_2776
MLE: ML1444
MLB: MLBr_01444
MPA: MAP1803 MAP2870
MAV: MAV_0487 MAV_2443 MAV_3654
MSM: MSMEG_2444 MSMEG_2669 MSMEG_3558
MUL: MUL_2272
MVA: Mvan_2379
MGI: Mflv_3311 Mflv_4008
MAB: MAB_3265c
MMC: Mmcs_2499 Mmcs_2750
MKM: Mkms_2544
MJL: Mjls_2536 Mjls_2780
MMI: MMAR_1955 MMAR_3032
NFA: nfa12500 nfa29410
RHA: RHA1_ro01784 RHA1_ro02271 RHA1_ro03727 RHA1_ro04129
RER: RER_03140 RER_52940 RER_54620
ROP: ROP_14570 ROP_19800 ROP_35450 ROP_40040
GBR: Gbro_0293 Gbro_4533
SCO: SCO7359(SC9H11.13c)
SMA: SAV_5965
CMI: CMM_1520
CMS: CMS_1783
ART: Arth_0598 Arth_3272
AAU: AAur_2327
ACH: Achl_1016 Achl_3068
RSA: RSal33209_2357 RSal33209_2854
MLU: Mlut_00900
BCV: Bcav_2276
BFA: Bfae_24560
TCU: Tcur_0468 Tcur_0949
SRO: Sros_3058 Sros_9126
FRA: Francci3_0536 Francci3_2614
FRE: Franean1_0608 Franean1_4124 Franean1_4876 Franean1_6096
FAL: FRAAL0697 FRAAL1029 FRAAL4887 FRAAL5270
ACE: Acel_1423 Acel_1445
NML: Namu_2943
KRA: Krad_3055
SEN: SACE_0218 SACE_4437 SACE_4781 SACE_5348
SVI: Svir_01840 Svir_07760
AMI: Amir_0147
STP: Strop_0898
SAQ: Sare_0841
CAI: Caci_1727 Caci_5204
AFO: Afer_0185 Afer_1783
ABA: Acid345_2787
ACA: ACP_0146 ACP_3300
SUS: Acid_3046 Acid_3528 Acid_5275
SRU: SRU_1703
RMR: Rmar_2600
CHU: CHU_0997
DFE: Dfer_3354
CPI: Cpin_4562
PHE: Phep_2950
FJO: Fjoh_4137
RBI: RB2501_09575
MIN: Minf_1062 Minf_1760
GAU: GAU_1240 GAU_2194
RBA: RB11146 RB5825 RB745 RB8248
SYN: sll1298(clcD)
SYW: SYNW0092 SYNW2419
SYC: syc0574_d syc1415_d(clcD)
SYF: Synpcc7942_0089 Synpcc7942_0969
SYD: Syncc9605_0084
SYG: sync_0089 sync_2412
SYR: SynRCC307_0089 SynRCC307_2421
SYX: SynWH7803_0144 SynWH7803_2450
SYP: SYNPCC7002_A2763
TEL: tlr1423
MAR: MAE_06360
CYT: cce_1445 cce_3136(clcD)
CYP: PCC8801_0420 PCC8801_3192 PCC8801_3312
CYC: PCC7424_1212 PCC7424_1279 PCC7424_1898 PCC7424_4626
CYN: Cyan7425_3285 Cyan7425_3405
CYH: Cyan8802_0431 Cyan8802_2805 Cyan8802_2927
GVI: gll3740 glr3401
ANA: all0955 alr1077 alr1362 alr4786
NPU: Npun_F0855 Npun_F1215 Npun_F1319 Npun_R4685
AVA: Ava_0533 Ava_2055 Ava_3733 Ava_4024 Ava_4152 Ava_C0110
PMT: PMT1031(clcD)
PMI: PMT9312_1497
PMF: P9303_10371
PMG: P9301_16031
TER: Tery_0392 Tery_2503
AMR: AM1_1706
RRS: RoseRS_2684
RCA: Rcas_2198
CAU: Caur_2628
CAG: Cagg_0896
CHL: Chy400_2841
HAU: Haur_4136
STI: Sthe_0109 Sthe_0115
AAE: aq_1997
HYA: HY04AAS1_1199
TTR: Tter_0298
MEM: Memar_0914
PTO: PTO1128
SSO: SSO2087(clcD)
STO: ST2511
SAI: Saci_1718
SIS: LS215_0450
SIA: M1425_0472
SIM: M1627_0485
SID: M164_0507
SIY: YG5714_0409
SIN: YN1551_2611
MSE: Msed_1285
CMA: Cmaq_1491
Taxonomy
Structures PDB: 1DIN  1GGV  1ZI6  1ZI8  1ZI9  1ZIC  1ZIX  1ZIY  1ZJ4  1ZJ5  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:7305906]
Schmidt E, Knackmuss HJ.
Chemical structure and biodegradability of halogenated aromatic
compounds. Conversion of chlorinated muconic acids into
maleoylacetic acid.
Biochem. J. 192 (1980) 339-47.
Pseudomonas sp.
Other DBs ExplorEnz - The Enzyme Database: 3.1.1.45
IUBMB Enzyme Nomenclature: 3.1.1.45
ExPASy - ENZYME nomenclature database: 3.1.1.45
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.45
BRENDA, the Enzyme Database: 3.1.1.45
CAS: 76689-22-0
DBGET integrated database retrieval system