KEGG   ENZYME: 3.1.1.51Help
Entry
EC 3.1.1.51                 Enzyme                                 

Name
phorbol-diester hydrolase;
diacylphorbate 12-hydrolase;
diacylphorbate 12-hydrolase;
phorbol-12,13-diester 12-ester hydrolase;
PDEH
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
12,13-diacylphorbate 12-acylhydrolase
Reaction(IUBMB)
phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate [RN:R04119]
Reaction(KEGG)
Substrate
phorbol 12,13-dibutanoate [CPD:C03634];
H2O [CPD:C00001]
Product
phorbol 13-butanoate [CPD:C03019];
butanoate [CPD:C00246]
Comment
Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.
History
EC 3.1.1.51 created 1984
Reference
1  [PMID:6946062]
  Authors
Shoyab M, Warren TC, Todaro GJ.
  Title
Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver.
  Journal
J. Biol. Chem. 256 (1981) 12529-34.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
81181-74-0

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