KEGG   ENZYME: 3.1.1.53Help
Entry
EC 3.1.1.53                 Enzyme                                 
Name
sialate O-acetylesterase;
N-acetylneuraminate acetyltransferase;
sialate 9(4)-O-acetylesterase;
sialidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
N-acyl-O-acetylneuraminate O-acetylhydrolase
Reaction(IUBMB)
N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate [RN:R01810]
Reaction(KEGG)
Substrate
N-acetyl-O-acetylneuraminate [CPD:C03708];
H2O [CPD:C00001]
Product
N-acetylneuraminate [CPD:C00270];
acetate [CPD:C00033]
Comment
Acts on free and glycosidically bound N-acetyl- or N-glycoloyl-neuraminic acid; acts mainly on the 4-O- and 9-O-acetyl groups. Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids.
Orthology
K05970  
sialate O-acetylesterase
Genes
HSA: 
54414(SIAE)
PTR: 
451636(SIAE)
PPS: 
100990394(SIAE)
GGO: 
101147182(SIAE)
PON: 
100171407(SIAE)
MCC: 
711816(SIAE)
MMU: 
22619(Siae)
RNO: 
363045(Siae)
CFA: 
489311(SIAE)
AML: 
100468858(SIAE)
FCA: 
101080322(SIAE)
BTA: 
507461(SIAE)
SSC: 
100521812(SIAE)
ECB: 
100072250(SIAE)
MDO: 
100017745
SHR: 
100920020(SIAE)
OAA: 
100086387
TGU: 
100223420(SIAE)
ACS: 
100565786
XLA: 
495015
XTR: 
100493404
DRE: 
555385(siae)
TRU: 
101072700
OLA: 
101163428
BFO: 
BRAFLDRAFT_217332 BRAFLDRAFT_217342
CIN: 
100177784 100181070
SPU: 
584468
NVE: 
NEMVE_v1g103646
HMG: 
100212614
AQU: 
100634259
XCC: 
XCC1753 XCC4103
XCB: 
XC_2482 XC_4194
XCA: 
xccb100_2509(siaE1) xccb100_4308(siaE2)
XCV: 
XCV1803 XCV4334
XCP: 
XCR_1993 XCR_4424
XAC: 
XAC1771 XAC4228
XAX: 
XACM_1794 XACM_4102
XAO: 
XAC29_08910 XAC29_21330
XOO: 
XOO4420
XOM: 
XOO_4163
XOP: 
PXO_03853
XOR: 
XOC_4469
XAL: 
XALc_0061 XALc_1193
XCI: 
XCAW_00067 XCAW_02295
SMZ: 
SMD_2234
PSU: 
Psesu_1044 Psesu_2926
CJA: 
CJA_3164
PAT: 
Patl_0830 Patl_1852
SDE: 
Sde_2492
AMAC: 
MASE_19150
AMK: 
AMBLS11_18450
AMAA: 
amad1_16230
GAG: 
Glaag_1839
TTU: 
TERTU_0681
CCR: 
CC_0798
CCS: 
CCNA_00840 CCNA_03151
CAK: 
Caul_1304 Caul_2403
CSE: 
Cseg_2003
AEX: 
Astex_1305 Astex_1707 Astex_1915 Astex_3535
HBA: 
Hbal_2793
NPP: 
PP1Y_Mpl1098
SJP: 
SJA_C2-02320
AXL: 
AXY_05460
LLK: 
LLKF_1374
LLS: 
lilo_1257
LLC: 
LACR_1436
LLM: 
llmg_1161 llmg_1162
LLN: 
LLNZ_05985 LLNZ_05990
LLI: 
uc509_1324
LJH: 
LJP_0442
PPE: 
PEPE_1762
CPY: 
Cphy_2658
CCE: 
Ccel_1262
CCB: 
Clocel_2697
CLB: 
Clo1100_0945 Clo1100_1830
ESR: 
ES1_08140
ESU: 
EUS_22520
BPB: 
bpr_I0174
CLE: 
Clole_0531 Clole_2593 Clole_3707
EHA: 
Ethha_0907
RAL: 
Rumal_1243 Rumal_2620
RCH: 
RUM_20850
CSC: 
Csac_0206
ATE: 
Athe_2722
COB: 
COB47_0714
CHD: 
Calhy_1902
COW: 
Calow_0631
CKI: 
Calkr_1927
CKN: 
Calkro_2542
CLC: 
Calla_1329
BLN: 
Blon_1907
BLON: 
BLIJ_1975
BLL: 
BLJ_1600
BAD: 
BAD_0083 BAD_0429
BLA: 
BLA_0139 BLA_1049
BLC: 
Balac_0149 Balac_0518
BLT: 
Balat_0149 Balat_0518
BBB: 
BIF_00477 BIF_01171
BBC: 
BLC1_0140 BLC1_0494
BNM: 
BALAC2494_00607 BALAC2494_00974
BLV: 
BalV_0145 BalV_0495
BLW: 
W7Y_0147 W7Y_0520
BLS: 
W91_0148 W91_0536
BNI: 
BANAN_00750 BANAN_02635
BDE: 
BDP_0122
BBV: 
HMPREF9228_1268
BAST: 
BAST_0233
BTP: 
D805_0123
CGO: 
Corgl_0562 Corgl_1694
STA: 
STHERM_c14530 STHERM_c16420
STQ: 
Spith_0778 Spith_1703
SBU: 
SpiBuddy_0216
ABA: 
Acid345_1697
ACA: 
ACP_0330 ACP_2739
ACM: 
AciX9_2674
GMA: 
AciX8_0969
TSA: 
AciPR4_0277
TRS: 
Terro_2943
SUS: 
Acid_2104 Acid_3201
BTH: 
BT_0457 BT_1779 BT_3124 BT_3132 BT_4091
BFR: 
BF1732 BF3493
BFS: 
BF1809(estS) BF3303
BFG: 
BF638R_1731(estS) BF638R_3330
BVU: 
BVU_0028 BVU_0738 BVU_2697 BVU_4140
BSA: 
Bacsa_1635
BXY: 
BXY_04090 BXY_21220 BXY_22860 BXY_31750 BXY_46620
PDI: 
BDI_0056 BDI_2948
PPN: 
Palpr_1641 Palpr_1819 Palpr_2304
OSP: 
Odosp_0542
TFO: 
BFO_2209
PRU: 
PRU_2599 PRU_2629
PMZ: 
HMPREF0659_A5850
PDN: 
HMPREF9137_2438
PDT: 
Prede_1619 Prede_1764
AFD: 
Alfi_2295
ASH: 
AL1_23340
RMR: 
Rmar_1628
RMG: 
Rhom172_1175
CPI: 
Cpin_1583 Cpin_4847
NKO: 
Niako_0753 Niako_1474 Niako_1957 Niako_2157
PHE: 
Phep_0760 Phep_1291 Phep_2308 Phep_2743 Phep_2783 Phep_3252
PSN: 
Pedsa_0322 Pedsa_1094 Pedsa_2434 Pedsa_2494 Pedsa_2708
SHG: 
Sph21_2348 Sph21_2657 Sph21_4286
SCN: 
Solca_1619
HHY: 
Halhy_1419 Halhy_4523
CMR: 
Cycma_1971
BBD: 
Belba_2158 Belba_3235
EVI: 
Echvi_1700 Echvi_2682 Echvi_4200 Echvi_4337
DFE: 
Dfer_0312 Dfer_3021
SLI: 
Slin_1080 Slin_1717 Slin_2622
LBY: 
Lbys_2334
RSI: 
Runsl_0017 Runsl_3649 Runsl_5721
EOL: 
Emtol_4138
FAE: 
FAES_2326 FAES_4348
FJO: 
Fjoh_0773 Fjoh_4232
COC: 
Coch_1034
ZPR: 
ZPR_3029
FBC: 
FB2170_02125 FB2170_03915
ZGA: 
zobellia_3175(siaE1) zobellia_3520(siaE2)
FBA: 
FIC_01735
OTE: 
Oter_1155 Oter_1337 Oter_3210
CAA: 
Caka_0463 Caka_1006
AMU: 
Amuc_0454
RBA: 
RB10048 RB6807 RB9651
PSL: 
Psta_3244
PLM: 
Plim_2636
PBS: 
Plabr_4446
IPA: 
Isop_1978
SACI: 
Sinac_6998
PHM: 
PSMK_17870
IAL: 
IALB_2692
 » show all
Taxonomy
Reference
1  [PMID:1991039]
  Authors
Garcia-Sastre A, Villar E, Manuguerra JC, Hannoun C, Cabezas JA.
  Title
Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds.
  Journal
Biochem. J. 273(Pt 2) (1991) 435-41.
  Organism
influenza C virus
Reference
2
  Authors
Shukla, A.K. and Schauer, R.
  Title
High performance liquid chromatography of enzymes of sialic acid metabolism.
  Journal
Hoppe-Seyler's Z. Physiol. Chem. 363 (1982) 1039-1040.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
89400-31-7
DBGET integrated database retrieval system