KEGG   ENZYME: 3.1.1.55Help
Entry
EC 3.1.1.55                 Enzyme                                 

Name
acetylsalicylate deacetylase;
aspirin esterase;
aspirin esterase;
acetylsalicylic acid esterase;
aspirin hydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
acetylsalicylate O-acetylhydrolase
Reaction(IUBMB)
acetylsalicylate + H2O = salicylate + acetate [RN:R02942]
Reaction(KEGG)
Substrate
acetylsalicylate [CPD:C01405];
H2O [CPD:C00001]
Product
salicylate [CPD:C00805];
acetate [CPD:C00033]
Comment
Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.
History
EC 3.1.1.55 created 1986, modified 1989
Reference
1  [PMID:6875867]
  Authors
Ali B, Kaur S.
  Title
Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases.
  Journal
J. Pharmacol. Exp. Ther. 226 (1983) 589-94.
  Organism
Rattus norvegicus
Reference
2  [PMID:2383281]
  Authors
Kim DH, Yang YS, Jakoby WB.
  Title
Aspirin hydrolyzing esterases from rat liver cytosol.
  Journal
Biochem. Pharmacol. 40 (1990) 481-7.
  Organism
Rattus norvegicus
Reference
3  [PMID:6704404]
  Authors
White KN, Hope DB.
  Title
Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver.
  Journal
Biochim. Biophys. Acta. 785 (1984) 138-47.
  Organism
Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87348-04-7

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