KEGG   ENZYME: 3.1.1.57Help
Entry
EC 3.1.1.57                 Enzyme                                 

Name
2-pyrone-4,6-dicarboxylate lactonase;
2-pyrone-4,6-dicarboxylate hydrolase;
2-pyrone-4,6-dicarboxylate lactonohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase
Reaction(IUBMB)
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN:R04277]
Reaction(KEGG)
Substrate
2-oxo-2H-pyran-4,6-dicarboxylate;
H2O [CPD:C00001]
Product
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD:C04434]
Comment
The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].
History
EC 3.1.1.57 created 1986, modified 2010
Pathway
Benzoate degradation
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K10221  
2-pyrone-4,6-dicarboxylate lactonase
Genes
SOD: 
SRH: 
SLM: 
VNA: 
VEJ: 
VFL: 
PPUH: 
PCG: 
PAT: 
AAW: 
MMW: 
MME: 
MPC: 
GSN: 
BPH: 
BPX: 
PTX: 
CDN: 
PHN: 
RFR: 
RSB: 
RHY: 
POL: 
PNA: 
ACK: 
ACRA: 
ACID: 
VEI: 
DAC: 
DEL: 
DTS: 
DHK: 
VAP: 
VPD: 
CTT: 
CTES: 
CKE: 
ADN: 
ADK: 
RTA: 
LIM: 
LIH: 
HYR: 
HYB: 
HYL: 
CBAA: 
CBAB: 
LCH: 
MIU: 
RGU: 
SHD: 
AZO: 
azo2539(ligI)
THU: 
TCL: 
MESO: 
ARA: 
RLE: 
pRL120277(ligI)
BRA: 
BRADO2340(ligI)
BBT: 
BBta_2700(ligI)
AOL: 
RPA: 
RPA4700(ligI)
RPB: 
RPD: 
RPE: 
RPT: 
RPX: 
RHZ: 
BSB: 
MALG: 
YAN: 
NAR: 
NPP: 
NPN: 
SMAZ: 
SPHI: 
SSAN: 
SPAN: 
SKR: 
SCH: 
SSY: 
SLG_12570(ligI)
SPHB: 
SPHR: 
SPHG: 
BLAS: 
AAY: 
WYH_01902(ligI)
ADO: 
CMAN: 
MAG: 
MAGX: 
XM1_1090(ligI)
MAGN: 
ABS: 
ABQ: 
MAGQ: 
PGV: 
ROA: 
SSX: 
SVL: 
SFA: 
SALB: 
STRP: 
SRC: 
STRF: 
STRD: 
KSK: 
KSE_75150(pcmC)
ART: 
ACH: 
APN: 
SATK: 
AMQ: 
PSEQ: 
PECQ: 
PHH: 
 » show all
Taxonomy
Reference
1  [PMID:7142106]
  Authors
Kersten PJ, Dagley S, Whittaker JW, Arciero DM, Lipscomb JD.
  Title
2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species.
  Journal
J. Bacteriol. 152 (1982) 1154-62.
Reference
2  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J. Biochem. (Tokyo). 93 (1983) 557-65.
Reference
3  [PMID:21219457]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol. Microbiol. 79 (2011) 359-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
84177-55-9

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