KEGG   ENZYME: 3.1.1.59Help
Entry
EC 3.1.1.59                 Enzyme                                 

Name
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Reaction(IUBMB)
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]
Reaction(KEGG)
Substrate
juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]
Product
juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]
Comment
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
History
EC 3.1.1.59 created 1989, modified 2015
Pathway
Insect hormone biosynthesis
Orthology
K01063  
juvenile-hormone esterase
Genes
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11161(Dsim_GD11161)
DWI: 
DYA: 
Dyak_GE11753(dyak_GLEANR_12059)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
TCA: 
658208(Tcjhe)
 » show all
Taxonomy
Reference
1
  Authors
de Kort, C.A.D. and Granger, N.A.
  Title
Regulation of the juvenile hormone titer.
  Journal
Annu. Rev. Entomol. 26 (1981) 1-28.
Reference
2
  Authors
Mitsui, T., Riddiford, L.M. and Bellamy, G.
  Title
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).
  Journal
Insect Biochem. 9 (1979) 637-643.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50812-15-2

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