KEGG   ENZYME: 3.1.1.59Help
Entry
EC 3.1.1.59                 Enzyme                                 

Name
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Reaction(IUBMB)
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]
Reaction(KEGG)
Substrate
juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]
Product
juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]
Comment
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
History
EC 3.1.1.59 created 1989, modified 2015
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K01063  juvenile-hormone esterase
Genes
DME: Dmel_CG8425(Jhe)
DPO: Dpse_GA25124
DAN: Dana_GF11292 Dana_GF11293
DER: Dere_GG20569
DPE: Dper_GL20599
DSE: Dsec_GM21660 Dsec_GM21661
DSI: Dsimw501_GD11160(Dsim_GD11160) Dsimw501_GD11161(Dsim_GD11161)
DWI: Dwil_GK15210 Dwil_GK15211 Dwil_GK21434 Dwil_GK21858 Dwil_GK21859 Dwil_GK21860 Dwil_GK21861 Dwil_GK21863 Dwil_GK21864 Dwil_GK22894 Dwil_GK22895 Dwil_GK27388 Dwil_GK27634 Dwil_GK27788 Dwil_GK27932
DYA: Dyak_GE11753
DGR: Dgri_GH23775
MDE: 101898361
AAG: 5566115
SOC: 105204452
ACEP: 105624427
TCA: 658208(Tcjhe)
DPA: 109544202
PRAP: 111001382
ZNE: 110830303
 » show all
Taxonomy
Reference
1
  Authors
de Kort, C.A.D. and Granger, N.A.
  Title
Regulation of the juvenile hormone titer.
  Journal
Annu. Rev. Entomol. 26 (1981) 1-28.
Reference
2
  Authors
Mitsui, T., Riddiford, L.M. and Bellamy, G.
  Title
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).
  Journal
Insect Biochem. 9 (1979) 637-643.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.59
IUBMB Enzyme Nomenclature: 3.1.1.59
ExPASy - ENZYME nomenclature database: 3.1.1.59
BRENDA, the Enzyme Database: 3.1.1.59
CAS: 50812-15-2

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