KEGG   ENZYME: 3.1.1.84Help
Entry
EC 3.1.1.84                 Enzyme                                 

Name
cocaine esterase;
CocE;
hCE2;
hCE-2;
human carboxylesterase 2
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
cocaine benzoylhydrolase
Reaction(IUBMB)
cocaine + H2O = ecgonine methyl ester + benzoate [RN:R06728]
Reaction(KEGG)
Substrate
cocaine [CPD:C01416];
H2O [CPD:C00001]
Product
ecgonine methyl ester [CPD:C12448];
benzoate [CPD:C00180]
Comment
Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].
History
EC 3.1.1.84 created 2010
Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K03927  
carboxylesterase 2
Genes
HSA: 
8824(CES2)
PTR: 
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
MCF: 
RRO: 
CJC: 
100400260(CES2)
MMU: 
102022(Ces2a) 234669(Ces2b) 234671(Ces2c) 234673(Ces2e) 436059(Ces2h) 72361(Ces2g)
RNO: 
100365112(Ces2) 100910144(Ces2) 171118(Ces2c) 246252(Ces2a) 291952(Ces2g) 498940(Ces2h) 679149 679368
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
102475270(CES2)
CFA: 
489769(CES2)
UMR: 
103673676(CES2)
FCA: 
PTG: 
102953134(CES2)
BTA: 
505928(CES2)
BOM: 
102275039(CES2)
PHD: 
102328178(CES2)
CHX: 
102175705(CES2)
OAS: 
101109730(CES2)
CFR: 
102510209(CES2)
BACU: 
103021148(CES2)
LVE: 
103072403(CES2)
ECB: 
100065668(CES2)
PALE: 
102881795(CES4A)
MDO: 
100144614(CES2.1) 100144616(CES2.3) 100144617(CES2.2)
SHR: 
GGA: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
102111003(CES2)
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
103067569(CES2)
GJA: 
XTR: 
DRE: 
561967(wu:fb62a02) 566132(ces2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SKO: 
DPO: 
DAN: 
DER: 
DPE: 
DSI: 
Dsimw501_GD23616(Dsim_GD23616)
DYA: 
Dyak_GE18855(dyak_GLEANR_2639)
DGR: 
DMO: 
DVI: 
MDE: 
TCA: 
API: 
CEL: 
CELE_F13H6.3(F13H6.3)
CBR: 
LGI: 
CRG: 
TMN: 
FGR: 
FPU: 
NHE: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_970144(AO090023000559)
ANG: 
ANI_1_216174(An10g00780) ANI_1_712104(An12g05590)
AFV: 
NFI: 
PCS: 
ABE: 
TVE: 
BZE: 
NPA: 
SHS: 
ACAN: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:18987161]
  Authors
Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG
  Title
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
  Journal
Mol. Pharmacol. 75 (2009) 318-23.
Reference
2  [PMID:10698749]
  Authors
Bresler MM, Rosser SJ, Basran A, Bruce NC
  Title
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from  Rhodococcus sp. strain MB1.
  Journal
Appl. Environ. Microbiol. 66 (2000) 904-8.
  Sequence
Reference
3  [PMID:1551831]
  Authors
Britt AJ, Bruce NC, Lowe CR
  Title
Identification of a cocaine esterase in a strain of Pseudomonas maltophilia.
  Journal
J. Bacteriol. 174 (1992) 2087-94.
Reference
4  [PMID:11742345]
  Authors
Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA
  Title
Crystal structure of a bacterial cocaine esterase.
  Journal
Nat. Struct. Biol. 9 (2002) 17-21.
  Sequence
Reference
5  [PMID:9169443]
  Authors
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF
  Title
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
  Journal
J. Biol. Chem. 272 (1997) 14769-75.
  Sequence
[hsa:8824]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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