KEGG   ENZYME: 3.1.1.90Help
Entry
EC 3.1.1.90                 Enzyme                                 

Name
all-trans-retinyl ester 13-cis isomerohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
all-trans-retinyl ester acylhydrolase, 13-cis retinol forming
Reaction(IUBMB)
an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid [RN:R09826]
Reaction(KEGG)
Substrate
all-trans-retinyl ester [CPD:C02075];
H2O [CPD:C00001]
Product
13-cis-retinol [CPD:C19962];
fatty acid [CPD:C00162]
Comment
All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine---retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.
History
EC 3.1.1.90 created 2011
Reference
1  [PMID:21235714]
  Authors
Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX
  Title
An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain.
  Journal
FEBS. J. 278 (2011) 973-87.
  Sequence
[dre:100002865]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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