KEGG   ENZYME: 3.1.1.93Help
Entry
EC 3.1.1.93                 Enzyme                                 

Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]
Reaction(KEGG)
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]
Product
mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Orthology
K13702  abhydrolase domain-containing protein 10
Genes
HSA: 55347(ABHD10)
PTR: 743016(ABHD10)
PPS: 100969335(ABHD10)
GGO: 101142961(ABHD10)
PON: 100171612(ABHD10)
NLE: 100581462(ABHD10)
MCC: 707464(ABHD10)
MCF: 102118678(ABHD10)
CSAB: 103228334(ABHD10)
RRO: 104660639(ABHD10)
RBB: 108539224(ABHD10)
CJC: 100393480(ABHD10)
SBQ: 101051108(ABHD10)
MMU: 213012(Abhd10)
RNO: 103693563 303953(Abhd10)
CGE: 100770127(Abhd10)
NGI: 103745090(Abhd10)
HGL: 101701879(Abhd10)
CCAN: 109681464(Abhd10)
OCU: 100350766(ABHD10)
TUP: 102474419(ABHD10)
CFA: 478561(ABHD10)
AML: 100476551(ABHD10)
UMR: 103677324(ABHD10)
ORO: 101366526(ABHD10)
FCA: 101086743(ABHD10)
PTG: 102971108(ABHD10)
AJU: 106972278(ABHD10)
BTA: 515563(ABHD10)
BOM: 102265166(ABHD10)
BIU: 109572046(ABHD10)
PHD: 102322852(ABHD10) 102330349
OAS: 101119354(ABHD10)
SSC: 100623142(ABHD10)
CFR: 102510750(ABHD10)
CDK: 105093220(ABHD10)
BACU: 103017939(ABHD10)
LVE: 103082279(ABHD10)
OOR: 101275519(ABHD10)
ECB: 100071551(ABHD10)
EPZ: 103557805(ABHD10)
EAI: 106844707(ABHD10)
MYB: 102262816(ABHD10)
HAI: 109374826(ABHD10)
RSS: 109436548(ABHD10)
PALE: 102894447(ABHD10)
LAV: 100668546(ABHD10)
TMU: 101352962
MDO: 100011506(ABHD10)
SHR: 100931213(ABHD10)
OAA: 100092679(ABHD10)
GGA: 418419(ABHD10)
MGP: 100549655(ABHD10)
CJO: 107321403(ABHD10)
APLA: 101796199(ABHD10)
ACYG: 106039267(ABHD10)
TGU: 100222969(ABHD10)
GFR: 102044285(ABHD10)
FAB: 101808891(ABHD10)
PHI: 102107053(ABHD10)
PMAJ: 107203157(ABHD10)
CCW: 104686992(ABHD10)
FPG: 101915956(ABHD10)
FCH: 102056155(ABHD10)
CLV: 102096483(ABHD10)
EGZ: 104131646(ABHD10)
AAM: 106490709(ABHD10)
ASN: 102385542(ABHD10)
AMJ: 106737278(ABHD10)
PSS: 102458815(ABHD10)
CMY: 102929983 102945397(ABHD10)
CPIC: 101934365(ABHD10) 103305912
ACS: 100568102(abhd10)
PVT: 110079017 110088006(ABHD10)
PBI: 103067679(ABHD10)
GJA: 107105909(ABHD10)
XLA: 108708114(abhd10.L)
XTR: 100135182(abhd10)
NPR: 108787367(ABHD10)
DRE: 492622(abhd10b) 568517(abhd10a)
TRU: 101064185(abhd10)
LCO: 104924970(abhd10)
NCC: 104963504(abhd10)
MZE: 101477718(abhd10)
OLA: 101158731(abhd10)
XMA: 102231232(abhd10)
PRET: 103456613(abhd10)
NFU: 107382881(abhd10)
CSEM: 103377136(abhd10)
LCF: 108881776(abhd10)
HCQ: 109530957(abhd10)
BPEC: 110160917(abhd10)
SFM: 108939604(abhd10)
LCM: 102363885 102365255(ABHD10)
CIN: 100179122
SPU: 577067
APLC: 110983539
SKO: 102804682
EPA: 110250931
 » show all
Taxonomy
Reference
1  [PMID:22294686]
  Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
  Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  Journal
J. Biol. Chem. 287 (2012) 9240-9.
  Sequence
[hsa:55347]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.93
IUBMB Enzyme Nomenclature: 3.1.1.93
ExPASy - ENZYME nomenclature database: 3.1.1.93
BRENDA, the Enzyme Database: 3.1.1.93

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