KEGG   ENZYME: 3.1.1.93Help
Entry
EC 3.1.1.93                 Enzyme                                 

Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]
Reaction(KEGG)
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]
Product
mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Orthology
K13702  
abhydrolase domain-containing protein 10
Genes
HSA: 
55347(ABHD10)
PTR: 
743016(ABHD10)
PPS: 
100969335(ABHD10)
GGO: 
101142961(ABHD10)
PON: 
100171612(ABHD10)
NLE: 
100581462(ABHD10)
MCC: 
707464(ABHD10)
MCF: 
102118678(ABHD10)
CJC: 
100393480(ABHD10)
MMU: 
213012(Abhd10)
RNO: 
303953(Abhd10)
CGE: 
100770127(Abhd10)
NGI: 
103745090(Abhd10)
HGL: 
101701879(Abhd10)
OCU: 
100350766(ABHD10)
TUP: 
102474419(ABHD10)
CFA: 
478561(ABHD10)
AML: 
UMR: 
103677324(ABHD10)
FCA: 
101086743(ABHD10)
PTG: 
102971108(ABHD10)
BTA: 
515563(ABHD10)
BOM: 
102265166(ABHD10)
PHD: 
CHX: 
102179045(ABHD10)
OAS: 
101119354(ABHD10)
SSC: 
100623142(ABHD10)
CFR: 
102510750(ABHD10)
BACU: 
103017939(ABHD10)
LVE: 
103082279(ABHD10)
ECB: 
100071551(ABHD10)
MYB: 
102262816(ABHD10)
PALE: 
102894447(ABHD10)
MDO: 
100011506(ABHD10)
SHR: 
100931213(ABHD10)
OAA: 
GGA: 
418419(ABHD10)
MGP: 
APLA: 
101796199(ABHD10)
TGU: 
100222969(ABHD10)
FAB: 
101808891(ABHD10)
PHI: 
102107053(ABHD10)
FPG: 
101915956(ABHD10)
FCH: 
102056155(ABHD10)
CLV: 
102096483(ABHD10)
ASN: 
102385542(ABHD10)
AMJ: 
102571886(ABHD10)
PSS: 
102458815(ABHD10)
CMY: 
ACS: 
100568102(abhd10)
PBI: 
103067679(ABHD10)
XTR: 
100135182(abhd10)
DRE: 
492622(abhd10b) 568517(abhd10a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
NVE: 
 » show all
Taxonomy
Reference
1  [PMID:22294686]
  Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
  Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  Journal
J. Biol. Chem. 287 (2012) 9240-9.
  Sequence
[hsa:55347]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system