KEGG   ENZYME: 3.1.1.93Help
Entry
EC 3.1.1.93                 Enzyme                                 

Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]
Reaction(KEGG)
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]
Product
mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Reference
1  [PMID:22294686]
  Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
  Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  Journal
J. Biol. Chem. 287 (2012) 9240-9.
  Sequence
[hsa:55347]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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