Entry |
|
Name |
aclacinomycin methylesterase;
RdmC;
aclacinomycin methyl esterase
|
Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
 |
Sysname |
aclacinomycin T acylhydrolase
|
Reaction(IUBMB) |
aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol [RN: R10545]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
15-demethylaclacinomycin T [CPD: C20689];
methanol [CPD: C00132]
|
Comment |
The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.
|
History |
EC 3.1.1.95 created 2013
|
Pathway |
| Biosynthesis of type II polyketide products | | Biosynthesis of antibiotics |
|
Orthology |
| aclacinomycin methylesterase |
|
Reference |
|
Authors |
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P |
Title |
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. |
Journal |
Biochim. Biophys. Acta. 1480 (2000) 191-200. |
Sequence |
|
Reference |
|
Authors |
Jansson A, Niemi J, Mantsala P, Schneider G |
Title |
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism. |
Journal |
J. Biol. Chem. 278 (2003) 39006-13. |
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |