KEGG   ENZYME: 3.1.1.95Help
Entry
EC 3.1.1.95                 Enzyme                                 

Name
aclacinomycin methylesterase;
RdmC;
aclacinomycin methyl esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
aclacinomycin T acylhydrolase
Reaction(IUBMB)
aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol [RN:R10545]
Reaction(KEGG)
R10545;
(other) R09337
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Substrate
aclacinomycin T [CPD:C18634];
H2O [CPD:C00001]
Product
15-demethylaclacinomycin T [CPD:C20689];
methanol [CPD:C00132]
Comment
The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.
History
EC 3.1.1.95 created 2013
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15957  
aclacinomycin methylesterase
Reference
1  [PMID:11004563]
  Authors
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
  Title
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
  Journal
Biochim. Biophys. Acta. 1480 (2000) 191-200.
  Sequence
Reference
2  [PMID:12878604]
  Authors
Jansson A, Niemi J, Mantsala P, Schneider G
  Title
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
  Journal
J. Biol. Chem. 278 (2003) 39006-13.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system