KEGG   ENZYME: 3.1.2.11Help
Entry
EC 3.1.2.11                 Enzyme                                 

Name
acetoacetyl-CoA hydrolase;
acetoacetyl coenzyme A hydrolase;
acetoacetyl CoA deacylase;
acetoacetyl coenzyme A deacylase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
acetoacetyl-CoA hydrolase
Reaction(IUBMB)
acetoacetyl-CoA + H2O = CoA + acetoacetate [RN:R01358]
Reaction(KEGG)
Substrate
acetoacetyl-CoA [CPD:C00332];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
acetoacetate [CPD:C00164]
History
EC 3.1.2.11 created 1972
Pathway
Butanoate metabolism
Reference
1  [PMID:6131897]
  Authors
Aragon JJ, Lowenstein JM.
  Title
A survey of enzymes which generate or use acetoacetyl thioesters in rat liver.
  Journal
J. Biol. Chem. 258 (1983) 4725-33.
Reference
2  [PMID:13818236]
  Authors
DRUMMOND GI, STERN JR.
  Title
Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver.
  Journal
J. Biol. Chem. 235 (1960) 318-25.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37288-10-1

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