KEGG   ENZYME: 3.1.2.16Help
Entry
EC 3.1.2.16                 Enzyme                                 

Name
citrate-lyase deacetylase;
[citrate-(pro-3S)-lyase] thiolesterase;
acetyl-S-(acyl-carrier protein) enzyme thioester hydrolase;
citrate lyase deacetylase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
[citrate-(pro-3S)-lyase](acetyl-form) hydrolase
Reaction(IUBMB)
[citrate (pro-3S)-lyase](acetyl form) + 6 H2O = [citrate (pro-3S)-lyase](thiol form) + 6 acetate [RN:R04450]
Reaction(KEGG)
Substrate
[citrate (pro-3S)-lyase](acetyl form) [CPD:C04334];
H2O [CPD:C00001]
Product
[citrate (pro-3S)-lyase](thiol form) [CPD:C04298];
acetate [CPD:C00033]
Comment
In the proteobacterium Rubrivivax gelatinosus, this enzyme modulates the activity of EC 4.1.3.6, citrate (pro-3S)-lyase, by converting it from its active acetyl form into its inactive thiol form by removal of its acetyl groups [2]. The activity of citrate-lyase deacetylase is itself inhibited by L-glutamate [2].
History
EC 3.1.2.16 created 1989
Reference
1  [PMID:356]
  Authors
Giffhorn F, Gottschalk G.
  Title
Inactivation of citrate lyase from Rhodopseudomonas gelatinosa by a specific deacetylase and inhibition of this inactivation by L-(+1-glutamate.
  Journal
J. Bacteriol. 124 (1975) 1052-61.
Reference
2  [PMID:7460909]
  Authors
Giffhorn F, Rode H, Kuhn A, Gottschalk G.
  Title
Citrate lyase deacetylase of Rhodopseudomonas gelatinosa. Isolation of the enzyme and studies on the inhibition by L-glutamate.
  Journal
Eur. J. Biochem. 111 (1980) 461-71.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
58319-93-0

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