KEGG   ENZYME: 3.1.2.19Help
Entry
EC 3.1.2.19                 Enzyme                                 

Name
ADP-dependent medium-chain-acyl-CoA hydrolase;
medium-chain acyl coenzyme A hydrolase;
medium-chain acyl-CoA hydrolase;
medium-chain acyl-thioester hydrolase;
medium-chain hydrolase;
myristoyl-CoA thioesterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
ADP-dependent-medium-chain-acyl-CoA hydrolase
Reaction(IUBMB)
acyl-CoA + H2O = CoA + a carboxylate [RN:R00383]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
carboxylate [CPD:C00060]
Comment
Requires ADP; inhibited by NADH. Maximum activity is shown with nonanoyl-CoA.
History
EC 3.1.2.19 created 1992
Orthology
K05976  
Genes
CVI: 
Taxonomy
Reference
1  [PMID:2901416]
  Authors
Alexson SE, Nedergaard J.
  Title
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.
  Journal
J. Biol. Chem. 263 (1988) 13564-71.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
63363-75-7

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