KEGG   ENZYME: 3.1.2.2Help
Entry
EC 3.1.2.2                  Enzyme                                 

Name
palmitoyl-CoA hydrolase;
long-chain fatty-acyl-CoA hydrolase;
palmitoyl coenzyme A hydrolase;
palmitoyl thioesterase;
palmitoyl coenzyme A hydrolase;
palmitoyl-CoA deacylase;
palmityl thioesterase;
palmityl-CoA deacylase;
fatty acyl thioesterase I;
palmityl thioesterase I
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
palmitoyl-CoA hydrolase
Reaction(IUBMB)
palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Reaction(KEGG)
Substrate
palmitoyl-CoA [CPD:C00154];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
palmitate [CPD:C00249]
Comment
Also hydrolyses CoA thioesters of other long-chain fatty acids.
History
EC 3.1.2.2 created 1961
Pathway
Fatty acid elongation
Biosynthesis of unsaturated fatty acids
Biosynthesis of secondary metabolites
Orthology
K00659  
bile acid-CoA:amino acid N-acyltransferase
K01068  
acyl-coenzyme A thioesterase 1/2/4
K17360  
acyl-coenzyme A thioesterase 7
Genes
HSA: 
10965(ACOT2) 11332(ACOT7) 122970(ACOT4) 570(BAAT) 641371(ACOT1)
PTR: 
100609278 453017(ACOT2) 453018(ACOT4) 472997(BAAT) 745616(ACOT7)
PPS: 
100971608(ACOT2) 100973111(ACOT4) 100977829(ACOT7) 100978366 100992429(BAAT)
GGO: 
101126562(ACOT7) 101139031(ACOT2) 101139653(ACOT4) 101140183(BAAT)
PON: 
100173009(ACOT7) 100431907(BAAT) 100442699(ACOT2) 100443692(ACOT4)
MCC: 
100429419(BAAT) 697011(ACOT2) 697131(ACOT4) 703288(ACOT7)
MCF: 
MMU: 
12012(Baat) 171210(Acot2) 171281(Acot3) 171282(Acot4) 217698(Acot5) 26897(Acot1) 70025(Acot7)
RNO: 
192272(Acot2) 26759(Acot7) 29725(Baat) 314304(Acot3) 503049(Acot5) 50559(Acot1) 681337(Acot4)
CGE: 
HGL: 
TUP: 
102472797 102473647(BAAT) 102478970(ACOT7) 102502559(ACOT4) 102502991(ACOT2)
CFA: 
479589(ACOT7) 481635(BAAT) 490770(ACOT2) 490771(ACOT4)
AML: 
FCA: 
101090371(ACOT7) 101092274(ACOT2) 101092524(ACOT4) 101095691 101096116(BAAT)
PTG: 
BTA: 
511033(ACOT2) 511431(ACOT4) 512541 514788(ACOT7) 530653 786798(BAAT)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
100050302(ACOT4) 100054567(BAAT) 100055927(ACOT2) 100059575(ACOT7)
MYB: 
MYD: 
PALE: 
MDO: 
100023136(BAAT) 100024487(ACOT2) 100026645(ACOT7)
SHR: 
OAA: 
GGA: 
419371(ACOT7) 428872(ACOT4) 769879(BAAT) 771753
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
XTR: 
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
NVE: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
CSV: 
RCU: 
POP: 
POPTR_0014s07900g(POPTRDRAFT_663966)
VVI: 
ZMA: 
SCE: 
YJR019C(TES1)
AGO: 
KLA: 
CGR: 
MGR: 
AOR: 
AOR_1_2070174(AO090005001196)
UMA: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:4871199]
  Authors
Barnes EM Jr, Wakil SJ.
  Title
Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase.
  Journal
J. Biol. Chem. 243 (1968) 2955-62.
  Organism
Escherichia coli
Reference
2  [PMID:6116156]
  Authors
Berge RK, Farstad M.
  Title
Long-chain fatty acyl-CoA hydrolase from rat liver mitochondria.
  Journal
Methods. Enzymol. 71 Pt C (1981) 234-42.
  Organism
Rattus norvegicus
Reference
3  [PMID:6115749]
  Authors
Miyazawa S, Furuta S, Hashimoto T.
  Title
Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators.
  Journal
Eur. J. Biochem. 117 (1981) 425-30.
  Organism
Rattus norvegicus
Reference
4  [PMID:13670899]
  Authors
SRERE PA, SEUBERT W, LYNEN F.
  Title
Palmityl coenzyme A deacylase.
  Journal
Biochim. Biophys. Acta. 33 (1959) 313-9.
  Organism
Sus scofa
Reference
5
  Authors
Yabusaki, K.K. and Ballou, C.E.
  Title
Long-chain fatty acyl-CoA thioesterases from Mycobacterium smegmatis.
  Journal
Methods Enzymol. 71 (1981) 242-246.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-87-0

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