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Entry
EC 3.1.2.20                 Enzyme                                 

Name
acyl-CoA hydrolase;
acyl coenzyme A thioesterase;
acyl-CoA thioesterase;
acyl coenzyme A hydrolase;
thioesterase B;
thioesterase II;
acyl-CoA thioesterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
acyl-CoA hydrolase
Reaction(IUBMB)
acyl-CoA + H2O = CoA + a carboxylate [RN:R00383]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
carboxylate [CPD:C00060]
Comment
Broad specificity for medium- to long-chain acyl-CoA. Insensitive to NAD+ (cf. EC 3.1.2.19 ADP-dependent medium-chain-acyl-CoA hydrolase)
History
EC 3.1.2.20 created 1992
Orthology
K01073  acyl-CoA hydrolase
Genes
ABO: ABO_1111
REH: H16_B1236(h16_B1236)
BMA: BMA0492
BMV: BMASAVP1_A2516
BML: BMA10229_A0890
BMN: BMA10247_0258
BPS: BPSL2470
BPM: BURPS1710b_2941
BPL: BURPS1106A_2888
BPD: BURPS668_2827
BPH: Bphy_0794
AZO: azo2123(tesA2)
SAT: SYN_01088
BAN: BA_2053
BAR: GBAA_2053
BAT: BAS1906
BAI: BAA_2120
BANT: A16_20890
BANR: A16R_21160
BANS: BAPAT_1962
BANV: DJ46_857
BCE: BC2038
BCA: BCE_2122
BCQ: BCQ_2038
BCX: BCA_2125
BNC: BCN_1968
BCF: bcf_10065
BCER: BCK_24375
BTL: BALH_1815
BTT: HD73_2216
BTHI: BTK_11190
BTM: MC28_1263
BTI: BTG_09750
BWW: bwei_2973(ykhA)
BMYC: DJ92_4605
BMYO: BG05_3939
LSA: LCA_0644
LSL: LSL_1721
LCA: LSEI_1984
TTH: TT_C1452
PTO: PTO0793
 » show all
Taxonomy
Reference
1  [PMID:2570608]
  Authors
Alexson SE, Svensson LT, Nedergaard J.
  Title
NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat.
  Journal
Biochim. Biophys. Acta. 1005 (1989) 13-9.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.20
IUBMB Enzyme Nomenclature: 3.1.2.20
ExPASy - ENZYME nomenclature database: 3.1.2.20
BRENDA, the Enzyme Database: 3.1.2.20
CAS: 37270-64-7

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