KEGG   ENZYME: 3.1.2.27Help
Entry
EC 3.1.2.27                 Enzyme                                 

Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Reaction(KEGG)
R07296;
(other) R03974
Show
Substrate
choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
CoA [CPD:C00010]
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
History
EC 3.1.2.27 created 2005
Pathway
Primary bile acid biosynthesis
Metabolic pathways
Orthology
K11992  
acyl-CoA thioesterase 8
Genes
HSA: 
10005(ACOT8)
PTR: 
458288(ACOT8)
PPS: 
100968654(ACOT8)
GGO: 
101153013(ACOT8)
PON: 
100173249(ACOT8)
NLE: 
100583641(ACOT8)
MCC: 
717238(ACOT8)
MCF: 
102141803(ACOT8)
CJC: 
100412346(ACOT8)
MMU: 
170789(Acot8)
RNO: 
170588(Acot8)
CGE: 
HGL: 
101723404(Acot8)
TUP: 
102482443(ACOT8)
CFA: 
477247(ACOT8)
AML: 
UMR: 
103669711(ACOT8)
FCA: 
101086550(ACOT8)
PTG: 
102970206(ACOT8)
BTA: 
504360(ACOT8)
BOM: 
102271157(ACOT8)
PHD: 
102324309(ACOT8)
CHX: 
102180774(ACOT8)
OAS: 
101115474(ACOT8)
SSC: 
100157173(ACOT8)
CFR: 
102506493(ACOT8)
BACU: 
103019412(ACOT8)
LVE: 
103089157(ACOT8)
ECB: 
100056378(ACOT8)
MYB: 
102256663(ACOT8)
MYD: 
102767910(ACOT8)
PALE: 
102886033(ACOT8)
MDO: 
100021873(ACOT8)
SHR: 
100932746(ACOT8)
GGA: 
419303(ACOT8)
APLA: 
TGU: 
100226822(ACOT8)
FAB: 
101812723(ACOT8)
PHI: 
102113815(ACOT8)
FPG: 
101912113(ACOT8)
FCH: 
102046223(ACOT8)
CLV: 
102088484(ACOT8)
ASN: 
102374940(ACOT8)
AMJ: 
102564482(ACOT8)
PSS: 
102459959(ACOT8)
CMY: 
102946356(ACOT8)
ACS: 
100554009(acot8)
PBI: 
103055025(ACOT8)
XTR: 
100495154(acot8)
DRE: 
450052(acot8)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353321(ACOT8)
CMK: 
103191249(acot8)
SPU: 
CEL: 
CELE_F25E2.3(F25E2.3)
CBR: 
TSP: 
HRO: 
LGI: 
TAD: 
ADL: 
LBC: 
SCM: 
ABV: 
AGABI2DRAFT189998(AGABI2DRAFT_189998)
SLA: 
MLR: 
TCR: 
 » show all
Taxonomy
Reference
1  [PMID:11673457]
  Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
  Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
  Journal
J. Biol. Chem. 277 (2002) 1128-38.
  Sequence
[mmu:170789]
Reference
2  [PMID:10817395]
  Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
  Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
  Journal
Scand. J. Clin. Lab. Invest. 60 (2000) 91-102.
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu. Rev. Biochem. 72 (2003) 137-74.
  Sequence
[mmu:12642]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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