KEGG   ENZYME: 3.1.2.27Help
Entry
EC 3.1.2.27                 Enzyme                                 
Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Reaction(KEGG)
R07296;
(other) R03974
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Substrate
choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
CoA [CPD:C00010]
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
Pathway
Primary bile acid biosynthesis
Metabolic pathways
Orthology
K11992  
acyl-CoA thioesterase 8
Genes
HSA: 
10005(ACOT8)
PTR: 
458288(ACOT8)
PPS: 
100968654(ACOT8)
GGO: 
101153013(ACOT8)
PON: 
100173249(ACOT8)
MCC: 
717238(ACOT8)
MMU: 
170789(Acot8)
RNO: 
170588(Acot8)
CFA: 
477247(ACOT8)
AML: 
FCA: 
101086550(ACOT8)
BTA: 
504360(ACOT8)
SSC: 
100157173(ACOT8)
ECB: 
100056378(ACOT8)
MDO: 
100021873
SHR: 
100932746(ACOT8)
GGA: 
419303(ACOT8)
TGU: 
100226822(ACOT8)
ACS: 
100554009
XTR: 
100495154
DRE: 
450052(acot8)
TRU: 
101074147
OLA: 
101168035
SPU: 
589369
CEL: 
CELE_F25E2.3(F25E2.3)
CBR: 
CBG08110 CBG24030
TSP: 
Tsp_10152
TAD: 
TRIADDRAFT_50197
LBC: 
LACBIDRAFT_301765
SCM: 
SCHCODRAFT_80675
 » show all
Taxonomy
Reference
1  [PMID:11673457]
  Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
  Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
  Journal
J. Biol. Chem. 277 (2002) 1128-38.
  Organism
Mus musculus [GN:mmu]
Reference
2  [PMID:10817395]
  Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
  Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
  Journal
Scand. J. Clin. Lab. Invest. 60 (2000) 91-102.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu. Rev. Biochem. 72 (2003) 137-74.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system