KEGG   ENZYME: 3.1.2.28Help
Entry
EC 3.1.2.28                 Enzyme                                 

Name
1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
menI (gene name);
ydiL (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Reaction(IUBMB)
1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA [RN:R07262]
Reaction(KEGG)
Substrate
1,4-dihydroxy-2-naphthoyl-CoA [CPD:C15547];
H2O [CPD:C00001]
Product
1,4-dihydroxy-2-naphthoate [CPD:C03657];
CoA [CPD:C00010]
Comment
This enzyme participates in the synthesis of menaquinones [4], phylloquinone [3], as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates [3].
History
EC 3.1.2.28 created 2010
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12073  1,4-dihydroxy-2-naphthoyl-CoA hydrolase
K19222  1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Genes
ECO: b1686(menI)
ECJ: JW1676(ydiI)
ECD: ECDH10B_1821(ydiI)
EBW: BWG_1500(ydiI)
ECOK: ECMDS42_1358(ydiI)
ECE: Z2714
ECS: ECs2393
ECF: ECH74115_2401(ydiL)
ETW: ECSP_2253(ydiI)
ELX: CDCO157_2227
EOJ: ECO26_2414(ydiI)
EOI: ECO111_2155(ydiI)
EOH: ECO103_1829(ydiI)
ECG: E2348C_1771(ydiI)
EOK: G2583_2082(ydiI)
ECC: c2081(ydiI)
ECP: ECP_1633
ECI: UTI89_C1878(ydiI)
ECV: APECO1_763(ydiI)
ECX: EcHS_A1767(ydiL)
ECW: EcE24377A_1902(ydiL)
ECM: EcSMS35_1510(ydiL)
ECY: ECSE_1809
ECR: ECIAI1_1738(ydiI)
ECQ: ECED1_1885(ydiI)
ECK: EC55989_1853(ydiI)
ECT: ECIAI39_1372(ydiI)
EOC: CE10_1960(ydiI)
EUM: ECUMN_1975(ydiI)
ECZ: ECS88_1736(ydiI)
ELH: ETEC_1719
ESE: ECSF_1546
ESO: O3O_13830
ESM: O3M_11770
ESL: O3K_11805
EBR: ECB_01655(ydiI)
EBD: ECBD_1960
EKF: KO11_14315(ydiI)
EAB: ECABU_c19400(ydiI)
EDJ: ECDH1ME8569_1630(ydiI)
EIH: ECOK1_1806(ydiL)
ENA: ECNA114_1733(ydiI)
ELW: ECW_m1854(ydiI)
ELL: WFL_09080(ydiI)
ELC: i14_1903(ydiI)
ELD: i02_1903(ydiI)
ELP: P12B_c1397(ydiL)
EBL: ECD_01655(menI)
EBE: B21_01644(ydiI)
ELF: LF82_2874(ydiI)
ECOI: ECOPMV1_01784(ydiI)
ECOJ: P423_09005
ECOS: EC958_1906(ydiI)
EFE: EFER_1366(ydiI)
EAL: EAKF1_ch4366(ydiL)
STY: STY1757
STT: t1234
STM: STM1366
SEB: STM474_1370(ydiI)
SENI: CY43_06950
SPT: SPA1489
SEK: SSPA1382
SEI: SPC_2363
SEC: SCH_1386(ydiI)
SHB: SU5_01983
SENS: Q786_08425
SED: SeD_A1977
SEG: SG1751
SEL: SPUL_1183
SET: SEN1679
SENA: AU38_08695
SENO: AU37_08700
SENV: AU39_08705
SENQ: AU40_09700
SENL: IY59_08890
SEEP: I137_05445
SENE: IA1_06735
SBG: SBG_1206
SBZ: A464_1399
SFL: SF1716
SFX: S1848
SFV: SFV_1709
SFE: SFxv_1923(ydiI)
SFN: SFy_2459
SFS: SFyv_2514
SFT: NCTC1_01861(ydiI)
SSN: SSON_1470
SBO: SBO_1444
SBC: SbBS512_E1887(ydiL)
SDY: SDY_1674
ENC: ECL_02386
ECLO: ENC_13900
EEC: EcWSU1_01843(ydiI)
ECLX: LI66_09270
ECLY: LI62_10045
ECLZ: LI64_09335
ESA: ESA_02096
CSK: ES15_2252
CTU: CTU_18690(ydiI)
KPN: KPN_02157(ydiI)
KPU: KP1_3258
KPP: A79E_2083
KPT: VK055_0301(ybdB)
KPE: KPK_2163(ydiI)
KPR: KPR_2705(ydiI)
KPJ: N559_2127
KPX: PMK1_04524(ydiI)
KPNU: LI86_10565
KPNK: BN49_3265(ydiI)
KVA: Kvar_2034
KOX: KOX_22835
KOE: A225_3445
EAE: EAE_17095
EAR: CCG30474
CKO: CKO_01721
CRO: ROD_13641
CAMA: F384_06210
EBT: EBL_c16680(ydiI)
EBF: D782_1960
PSTS: E05_19450
YPE: YPO2406
YPK: y1933
YPA: YPA_1750
YPN: YPN_1860
YPM: YP_2193(paaI1)
YPG: YpAngola_A2595(ydiI)
YPZ: YPZ3_1481
YPD: YPD4_1446
YPX: YPD8_1499
YPH: YPC_2039(ydiI)
YPW: CH59_4240(ydiI)
YPJ: CH55_481(ydiI)
YPV: BZ15_1119(ydiI)
YPL: CH46_2699(ydiI)
YPS: YPTB2315
YPO: BZ17_139(ydiI)
YPI: YpsIP31758_1740(ydiI)
YPY: YPK_1846
YPB: YPTS_2389
YPQ: DJ40_4270(ydiI)
YPU: BZ21_1603(ydiI)
YPR: BZ20_3928(ydiI)
YPC: BZ23_1889(ydiI)
YPF: BZ19_1681
YEN: YE2173
YEY: Y11_08171
YEW: CH47_1609(ydiI)
YET: CH48_3649
YAL: AT01_278
YFR: AW19_1380(ydiI)
YIN: CH53_4117
YKR: CH54_282
YRO: CH64_719
YRU: BD65_461(ydiI)
SPE: Spro_2177
SRL: SOD_c19910(ydiI)
SPLY: Q5A_011095(menI)
SMAF: D781_2027
SMW: SMWW4_v1c22060(ydiI)
SMAR: SM39_1639
SERF: L085_17735
RAA: Q7S_13955
ECA: ECA1857
PATR: EV46_08895
PATO: GZ59_27460
PCT: PC1_2452
PEC: W5S_2736
SOD: Sant_2059
EBI: EbC_18990(ydiI)
EGE: EM595_0480(entH)
PLU: plu2625
PAY: PAU_01905
PMR: PMI1418
XBO: XBJ1_2507
XBV: XBW1_2989(ydiI)
XNE: XNC1_1865
XNM: XNC2_1810
XDO: XDD1_1846(ydiI)
XPO: XPG1_1570(ydiI)
PSI: S70_19485
PSX: DR96_2806(ydiI)
PRG: RB151_019400(ydiI)
MMK: MU9_2415
ETR: ETAE_1783
ETD: ETAF_1612
ETE: ETEE_3829
PSHI: SAMEA2665130_1681(ydiI)
DKO: I596_41
MICC: AUP74_00389(ydiI)
KGE: TQ33_0145
ASA: ASA_2500
AMED: B224_2867
NEU: NE0832
NET: Neut_1337
SCL: sce3016
BBAT: Bdt_0534
BBW: BDW_01930
BBAC: EP01_17120
BMX: BMS_3336
SPHM: G432_02295
AEQ: AEQU_0259
SYN: slr0204
SYY: SYNGTS_2465(slr0204)
SYT: SYNGTI_2464(slr0204)
SYS: SYNPCCN_2463(slr0204)
SYQ: SYNPCCP_2463(slr0204)
SYJ: D082_32600(ycf83)
SYW: SYNW2301
SYC: syc2347_c
SYG: sync_2650
SYNR: KR49_07770
SYND: KR52_03900
TEL: tll0488(ycf83)
THN: NK55_08595(dncH)
LBO: LBWT_9980
PMA: Pro_0198(fcbC)
PMM: PMM0173
PMT: PMT_2055
PMH: P9215_01911(fcbC)
PRC: EW14_0216
PRM: EW15_0262
AMR: AM1_3146
MAR: MAE_08510
MPK: VL20_1046
CYT: cce_1832
TER: Tery_4064
ANA: alr2465
AVA: Ava_0397
NAZ: Aazo_1390
CALH: IJ00_14495
CTHE: Chro_4089
PUV: PUV_02610
WCH: wcw_0460
OTE: Oter_2808
RMR: Rmar_1468
FLN: FLA_5923
SGN: SGRA_3175
SMIZ: 4412673_00403(ydiI)
SLI: Slin_2909
LBY: Lbys_3104
FLM: MY04_0134
RAG: B739_0167
RAE: G148_1892
RAT: M949_0603
CTS: Ctha_2251
IAL: IALB_1315
MRO: MROS_1444
 » show all
Taxonomy
Reference
1
  Authors
Muller, W. and Leistner, E.
  Title
1,4-Naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis.
  Journal
Phytochemistry 15 (1976) 407-410.
Reference
2
  Authors
Eichinger, D., Bacher, A., Zenk, M.H. and Eisenreich, W.
  Title
Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum.
  Journal
J. Am. Chem. Soc. 121 (1999) 7469-7475.
Reference
3  [PMID:19321747]
  Authors
Widhalm JR, van Oostende C, Furt F, Basset GJ.
  Title
A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 5599-603.
  Sequence
[syn:slr0204]
Reference
4  [PMID:23564174]
  Authors
Chen M, Ma X, Chen X, Jiang M, Song H, Guo Z
  Title
Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.
  Journal
J. Bacteriol. 195 (2013) 2768-75.
  Sequence
[eco:b1686]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.28
IUBMB Enzyme Nomenclature: 3.1.2.28
ExPASy - ENZYME nomenclature database: 3.1.2.28
BRENDA, the Enzyme Database: 3.1.2.28

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