KEGG   ENZYME: 3.1.2.30Help
Entry
EC 3.1.2.30                 Enzyme                                 

Name
(3S)-malyl-CoA thioesterase;
mcl2 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
(S)-malyl-CoA hydrolase
Reaction(IUBMB)
(S)-malyl-CoA + H2O = (S)-malate + CoA [RN:R10612]
Reaction(KEGG)
Substrate
(S)-malyl-CoA [CPD:C04348];
H2O [CPD:C00001]
Product
(S)-malate [CPD:C00149];
CoA [CPD:C00010]
Comment
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
History
EC 3.1.2.30 created 2014
Pathway
Glyoxylate and dicarboxylate metabolism
Microbial metabolism in diverse environments
Orthology
K14451  
(3S)-malyl-CoA thioesterase
K19282  
bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
SIL: 
SPO0352(citE)
SIT: 
RSP: 
RSH: 
RSQ: 
RSK: 
RCP: 
JAN: 
RDE: 
RD1_1620(citE)
RLI: 
PDE: 
PAMI: 
DSH: 
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
LMD: 
RED: 
HMA: 
rrnAC1965(aceB)
HHI: 
HAH_2476(aceB)
HHN: 
HAB: 
NPH: 
NP_4430A(aceB)
NMO: 
Nmlp_2357(aceB)
HWA: 
HQ_1720A(aceB)
HWC: 
Hqrw_1842(aceB)
HVO: 
HVO_1983(aceB1) HVO_B0200(aceB2)
HME: 
HFX_2078(aceB)
HBO: 
HTU: 
NMG: 
NOU: 
 » show all
Taxonomy
Reference
1  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and  (3S)- Malyl-CoA thioesterase.
  Journal
J. Bacteriol. 192 (2010) 1249-58.
  Sequence
[rsp:RSP_0970]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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