KEGG   ENZYME: 3.1.2.31Help
Entry
EC 3.1.2.31                 Enzyme                                 

Name
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase;
LovG
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
dihydromonacolin L-[lovastatin nonaketide synthase] hydrolase
Reaction(IUBMB)
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
Reaction(KEGG)
(other) R11187
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Substrate
dihydromonacolin L-[lovastatin nonaketide synthase];
H2O [CPD:C00001]
Product
holo-[lovastatin nonaketide synthase];
dihydromonacolin L acid [CPD:C20851]
Comment
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
History
EC 3.1.2.31 created 2015
Reference
1  [PMID:23653178]
  Authors
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
  Title
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
  Journal
Angew. Chem. Int. Ed. Engl. 52 (2013) 6472-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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