KEGG   ENZYME: 3.1.21.6Help
Entry
EC 3.1.21.6                 Enzyme                                 

Name
CC-preferring endodeoxyribonuclease;
Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease
Class
Hydrolases;
Acting on ester bonds;
Endodeoxyribonucleases producing 5'-phosphomonoesters
BRITE hierarchy
Reaction(IUBMB)
endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC
Comment
Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4[1] may be the same enzyme.
History
EC 3.1.21.6 created 1999
Reference
1  [PMID:3186439]
  Authors
Xia YN, Morgan R, Schildkraut I, Van Etten JL.
  Title
A site-specific single strand endonuclease activity induced by NYs-1 virus infection of a Chlorella-like green alga.
  Journal
Nucleic. Acids. Res. 16 (1988) 9477-87.
Reference
2  [PMID:1533367]
  Authors
Aparicio JF, Freije JM, Lopez-Otin C, Cal S, Sanchez J.
  Title
A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide.
  Journal
Eur. J. Biochem. 205 (1992) 695-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37211-67-9

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