KEGG   ENZYME: 3.1.3.24Help
Entry
EC 3.1.3.24                 Enzyme                                 

Name
sucrose-phosphate phosphatase;
sucrose 6-phosphate hydrolase;
sucrose-phosphate hydrolase;
sucrose-phosphate phosphohydrolase;
sucrose-6-phosphatase;
sucrose phosphatase;
sucrose-6-phosphate phosphatase;
SPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
sucrose-6F-phosphate phosphohydrolase
Reaction(IUBMB)
sucrose 6F-phosphate + H2O = sucrose + phosphate [RN:R00805 R06211]
Reaction(KEGG)
Substrate
sucrose 6F-phosphate [CPD:C02591];
H2O [CPD:C00001]
Product
sucrose [CPD:C00089];
phosphate [CPD:C00009]
Comment
Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F of sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
History
EC 3.1.3.24 created 1972, modified 2008
Pathway
Starch and sucrose metabolism
Metabolic pathways
Reference
1  [PMID:4290548]
  Authors
Hawker JS, Hatch MD.
  Title
A specific sucrose phosphatase from plant tissues.
  Journal
Biochem. J. 99 (1966) 102-7.
Reference
2  [PMID:11050182]
  Authors
Lunn JE, Ashton AR, Hatch MD, Heldt HW
  Title
Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 12914-9.
  Sequence
[zma:541868] [osa:4328274] [ath:AT2G35840 AT3G54270]
Reference
3  [PMID:12753969]
  Authors
Lunn JE, MacRae E
  Title
New complexities in the synthesis of sucrose.
  Journal
Curr. Opin. Plant. Biol. 6 (2003) 208-14.
Reference
4  [PMID:15937230]
  Authors
Fieulaine S, Lunn JE, Borel F, Ferrer JL
  Title
The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
  Journal
Plant. Cell. 17 (2005) 2049-58.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-33-0

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