KEGG   ENZYME: 3.1.3.52Help
Entry
EC 3.1.3.52                 Enzyme                                 

Name
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase;
branched-chain oxo-acid dehydrogenase phosphatase;
branched-chain 2-keto acid dehydrogenase phosphatase;
branched-chain alpha-keto acid dehydrogenase phosphatase;
BCKDH;
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase;
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase
Reaction(IUBMB)
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O = [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate
Reaction(KEGG)
(other) R03515
Show
Substrate
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate [CPD:C01308];
H2O [CPD:C00001]
Product
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] [CPD:C04726];
phosphate [CPD:C00009]
Comment
A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation.
History
EC 3.1.3.52 created 1986
Reference
1  [PMID:6307746]
  Authors
Fatania HR, Patston PA, Randle PJ.
  Title
Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase.
  Journal
FEBS. Lett. 158 (1983) 234-8.
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr. Top. Cell. Regul. 27 (1985) 41-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87244-20-0 88086-29-7

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