KEGG   ENZYME: 3.1.3.56Help
Entry
EC 3.1.3.56                 Enzyme                                 
Name
inositol-polyphosphate 5-phosphatase;
type I inositol-polyphosphate phosphatase;
inositol trisphosphate phosphomonoesterase;
InsP3/Ins(1,3,4,5)P4 5-phosphatase;
inosine triphosphatase;
D-myo-inositol 1,4,5-triphosphate 5-phosphatase;
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase;
L-myo-inositol 1,4,5-trisphosphate-monoesterase;
inositol phosphate 5-phosphomonoesterase;
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase;
Ins(1,4,5)P3 5-phosphatase;
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase;
inositol 1,4,5-trisphosphate phosphatase;
inositol polyphosphate-5-phosphatase;
myo-inositol-1,4,5-trisphosphate 5-phosphatase;
inositol-1,4,5-trisphosphate 5-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394];
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Reaction(KEGG)
Substrate
D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
H2O [CPD:C00001];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272]
Product
myo-inositol 1,4-bisphosphate [CPD:C01220];
phosphate [CPD:C00009];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Comment
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01106  
inositol-1,4,5-trisphosphate 5-phosphatase
Genes
HSA: 
27124(INPP5J) 3632(INPP5A) 51763(INPP5K)
PTR: 
454410(INPP5K) 458767(INPP5J) 747128(INPP5A)
PPS: 
100976910(INPP5K) 100980932(INPP5J) 100995871(INPP5A)
GGO: 
101124081(INPP5K) 101127025(INPP5J) 101137047
PON: 
100440857(INPP5A) 100457320(INPP5J)
MCC: 
718308(INPP5J) 719508 721222(INPP5K)
MMU: 
170835(Inpp5j) 19062(Inpp5k) 212111(Inpp5a)
RNO: 
171088(Inpp5j) 287533(Inpp5k) 365382(Inpp5a)
CFA: 
403937(INPP5A) 480647(INPP5K) 486360(INPP5J)
AML: 
FCA: 
101083037(INPP5A) 101085842(INPP5K) 101095688(INPP5J)
BTA: 
514123(INPP5K) 514307(INPP5J) 615232(INPP5A)
SSC: 
100462756(INPP5K) 100510987 100512501(INPP5A)
ECB: 
100051027(INPP5A) 100058547(INPP5J) 100072370
MDO: 
100028528 100619651
SHR: 
100914690 100916010(INPP5J) 100927613(INPP5K)
OAA: 
100075999(INPP5J) 100093027
GGA: 
416996(INPP5J) 423973(INPP5A) 771549(INPP5K)
MGP: 
100538550 100546269 100548603(INPP5A)
TGU: 
100218210(INPP5A) 100221510(INPP5J) 100231908(INPP5K)
ACS: 
100552188 100553401
XLA: 
447532(inpp5a.1)
XTR: 
100127685(inpp5k) 548959(inpp5a.1) 779554(inpp5j)
DRE: 
100037338(inpp5k) 100317089(inpp5jb) 569568 641571
TRU: 
101070552 101071038 101075361
OLA: 
101156112 101173869
BFO: 
BRAFLDRAFT_243393
CIN: 
100175970 100178482
SPU: 
575498 576800
DME: 
Dmel_CG42283(5PtaseI) Dmel_CG9784
DPO: 
Dpse_GA16016
AGA: 
AgaP_AGAP000203 AgaP_AGAP011644
AAG: 
AaeL_AAEL000840 AaeL_AAEL013891 AaeL_AAEL014247
CQU: 
CpipJ_CPIJ006698 CpipJ_CPIJ008163
AME: 
406096 408730
NVI: 
100117462(NV17783) 100123979(NV10342)
TCA: 
659746 662279
API: 
100164453 100164713
PHU: 
Phum_PHUM014890 Phum_PHUM456270
ISC: 
IscW_ISCW018837
CEL: 
CELE_C09B8.1(ipp-5)
CBR: 
CBG14816(Cbr-ipp-5)
TSP: 
Tsp_06539 Tsp_10192
SMM: 
Smp_050830
NVE: 
NEMVE_v1g196982 NEMVE_v1g248701
TAD: 
TRIADDRAFT_31282
AQU: 
100641876
SCE: 
YNL106C(INP52) YOL065C(INP54) YOR109W(INP53)
KLA: 
KLLA0D13860g
CGR: 
CAGL0C05269g
PIC: 
PICST_58872(INP51) PICST_82710(INP52)
UMA: 
UM02595.1
MBR: 
MONBRDRAFT_33207
CPV: 
cgd2_230
TBR: 
Tb09.160.4180 Tb11.02.4140
TCR: 
506297.200 510101.130
LMA: 
LMJF_11_1010
LIF: 
LINJ_11_1010
 » show all
Taxonomy
Reference
1  [PMID:6285891]
  Authors
Downes CP, Mussat MC, Michell RH.
  Title
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
  Journal
Biochem. J. 203 (1982) 169-77.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2540972]
  Authors
Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE.
  Title
Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain.
  Journal
Eur. J. Biochem. 181 (1989) 317-22.
  Organism
Bos taurus [GN:bta]
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Reference
4  [PMID:8198557]
  Authors
Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C.
  Title
Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem. J. 300 ( Pt 1) (1994) 85-90.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
106283-14-1
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