KEGG   ENZYME: 3.1.3.56Help
Entry
EC 3.1.3.56                 Enzyme                                 

Name
inositol-polyphosphate 5-phosphatase;
type I inositol-polyphosphate phosphatase;
inositol trisphosphate phosphomonoesterase;
InsP3/Ins(1,3,4,5)P4 5-phosphatase;
inosine triphosphatase;
D-myo-inositol 1,4,5-triphosphate 5-phosphatase;
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase;
L-myo-inositol 1,4,5-trisphosphate-monoesterase;
inositol phosphate 5-phosphomonoesterase;
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase;
Ins(1,4,5)P3 5-phosphatase;
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase;
inositol 1,4,5-trisphosphate phosphatase;
inositol polyphosphate-5-phosphatase;
myo-inositol-1,4,5-trisphosphate 5-phosphatase;
inositol-1,4,5-trisphosphate 5-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394];
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Reaction(KEGG)
Substrate
D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
H2O [CPD:C00001];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272]
Product
myo-inositol 1,4-bisphosphate [CPD:C01220];
phosphate [CPD:C00009];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Comment
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
History
EC 3.1.3.56 created 1989, modified 2002
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01106  
inositol-1,4,5-trisphosphate 5-phosphatase
Genes
HSA: 
27124(INPP5J) 3632(INPP5A) 51763(INPP5K)
PTR: 
454410(INPP5K) 458767(INPP5J) 747128(INPP5A)
PPS: 
100976910(INPP5K) 100980932(INPP5J) 100995871(INPP5A)
GGO: 
PON: 
100440857(INPP5A) 100457320(INPP5J)
MCC: 
718308(INPP5J) 719508 721222(INPP5K)
MCF: 
101867263 102124549(INPP5A) 102139212(INPP5J)
MMU: 
170835(Inpp5j) 19062(Inpp5k) 212111(Inpp5a)
RNO: 
171088(Inpp5j) 287533(Inpp5k) 365382(Inpp5a)
CGE: 
100760037(Inpp5a) 100761777(Inpp5j) 100764873(Inpp5k)
HGL: 
101704617(Inpp5a) 101719531(Inpp5k) 101726724(Inpp5j)
TUP: 
102474778(INPP5J) 102485414(INPP5A) 102490192(INPP5K)
CFA: 
403937(INPP5A) 480647(INPP5K) 486360(INPP5J)
AML: 
FCA: 
101083037(INPP5A) 101085842(INPP5K) 101095688(INPP5J)
PTG: 
102951376(INPP5J) 102951654(INPP5A) 102971559(INPP5K)
BTA: 
514123(INPP5K) 514307(INPP5J) 615232(INPP5A)
BOM: 
102279605(INPP5K) 102284010(INPP5J) 102285484
PHD: 
102318041(INPP5J) 102324043 102330783(INPP5K)
CHX: 
102171365(INPP5J) 102177657(INPP5K) 102181924
OAS: 
101103674(INPP5J) 101110014 101115806(INPP5K)
SSC: 
100462756(INPP5K) 100510987(INPP5J) 100512501(INPP5A)
CFR: 
102510594(INPP5A) 102513746(INPP5K) 102521192
BACU: 
103000099(INPP5K) 103017049(INPP5J) 103018455(INPP5A)
LVE: 
103086449(INPP5K) 103088886(INPP5A) 103089080(INPP5J)
ECB: 
100051027(INPP5A) 100058547(INPP5J) 100072370(INPP5K)
MYB: 
102251847(INPP5K) 102254511 102256211(INPP5J) 102256550(INPP5A)
MYD: 
102759392(INPP5K) 102770814(INPP5A) 102770954(INPP5J)
PALE: 
102886374(INPP5K) 102886411(INPP5A) 102894864(INPP5J)
MDO: 
100028528(INPP5J) 100619651(INPP5K)
SHR: 
100914690 100916010(INPP5J) 100927613(INPP5K)
OAA: 
100075999(INPP5J) 100089552(INPP5K) 100093027(INPP5A)
GGA: 
416996(INPP5J) 423973(INPP5A) 771549(INPP5K)
MGP: 
TGU: 
100218210(INPP5A) 100221510(INPP5J) 100231908(INPP5K)
FAB: 
101806643(INPP5K) 101810436(INPP5J) 101814745(INPP5A)
PHI: 
102099529(INPP5A) 102101343(INPP5K) 102114523(INPP5J)
APLA: 
101790657(INPP5J) 101798206(INPP5K) 101804204(INPP5A)
FPG: 
101918225(INPP5K) 101918251(INPP5J) 101924782(INPP5A)
FCH: 
102050343(INPP5J) 102052658(INPP5K) 102054445(INPP5A)
CLV: 
102088610(INPP5K) 102090809(INPP5A) 102097794(INPP5J)
ASN: 
AMJ: 
102559502(INPP5A) 102559762(INPP5K) 102568710 102572423(INPP5J)
PSS: 
102447470(INPP5A) 102451462 102464080(INPP5K)
CMY: 
102929515(INPP5A) 102943056(INPP5J) 102944286(INPP5K)
ACS: 
PBI: 
XLA: 
447532(inpp5a.1)
XTR: 
100127685(inpp5k) 548959(inpp5a.1) 779554(inpp5j)
DRE: 
100037338(inpp5ka) 100317089(inpp5jb) 566188(inpp5kb) 569568 641571
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180430(inpp5a) 103180576(inpp5k) 103184062(inpp5j) 103188986
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
AGA: 
AAG: 
CQU: 
AME: 
406096(GB12514) 408730(GB12104)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG14816(Cbr-ipp-5)
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CIC: 
TCC: 
GMX: 
PVU: 
FVE: 
PPER: 
SLY: 
SOT: 
SBI: 
SORBI_01g014230(SORBIDRAFT_01g014230)
ZMA: 
SMO: 
PPP: 
SCE: 
YNL106C(INP52) YOL065C(INP54) YOR109W(INP53)
KLA: 
CGR: 
PIC: 
PICST_58872(INP51) PICST_82710(INP52)
UMA: 
MBR: 
CPV: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
 » show all
Taxonomy
Reference
1  [PMID:6285891]
  Authors
Downes CP, Mussat MC, Michell RH.
  Title
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
  Journal
Biochem. J. 203 (1982) 169-77.
  Organism
Homo sapiens
Reference
2  [PMID:2540972]
  Authors
Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE.
  Title
Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain.
  Journal
Eur. J. Biochem. 181 (1989) 317-22.
  Organism
Bos taurus
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Reference
4  [PMID:8198557]
  Authors
Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C.
  Title
Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem. J. 300 ( Pt 1) (1994) 85-90.
  Organism
Bos taurus, Canis familiaris
  Sequence
[cfa:403937]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
106283-14-1

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