KEGG   ENZYME: 3.1.3.62Help
Entry
EC 3.1.3.62                 Enzyme                                 

Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
History
EC 3.1.3.62 created 1992, modified 2002
Pathway
Inositol phosphate metabolism
Orthology
K03103  
multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 
9562(MINPP1)
PTR: 
450579(MINPP1)
PPS: 
100980933(MINPP1)
GGO: 
101144263(MINPP1)
PON: 
100173135(MINPP1)
NLE: 
100602225(MINPP1)
MCC: 
704362(MINPP1)
MCF: 
101925472(MINPP1)
CSAB: 
103216204(MINPP1)
RRO: 
104675164(MINPP1)
CJC: 
100391750(MINPP1)
MMU: 
17330(Minpp1)
RNO: 
29688(Minpp1)
CGE: 
100766430(Minpp1)
NGI: 
103738050(Minpp1)
HGL: 
101711589(Minpp1)
CCAN: 
109681827(Minpp1)
OCU: 
TUP: 
102484201(MINPP1)
CFA: 
486462(MINPP1)
AML: 
100468979(MINPP1)
UMR: 
103661917(MINPP1)
FCA: 
101091150(MINPP1)
PTG: 
102971475(MINPP1)
AJU: 
106980974(MINPP1)
BTA: 
541067(MINPP1)
BOM: 
102266889(MINPP1)
BIU: 
109553098(MINPP1)
PHD: 
102338873(MINPP1)
CHX: 
102187288(MINPP1)
OAS: 
101118833(MINPP1)
SSC: 
100152243(MINPP1)
CFR: 
102522901(MINPP1)
BACU: 
103015775(MINPP1)
LVE: 
103073572(MINPP1)
ECB: 
100062448(MINPP1)
MYB: 
102256717(MINPP1)
MYD: 
102754386(MINPP1)
HAI: 
109387537(MINPP1)
RSS: 
PALE: 
102882782(MINPP1)
LAV: 
100661711(MINPP1)
MDO: 
100022488(MINPP1)
SHR: 
100924973(MINPP1)
GGA: 
395356(MINPP1)
MGP: 
100540797(MINPP1)
CJO: 
107315617(MINPP1)
APLA: 
101798501(MINPP1)
TGU: 
100225117(MINPP1)
GFR: 
102040581(MINPP1)
FAB: 
101807959(MINPP1)
PHI: 
102106327(MINPP1)
CCW: 
104695103(MINPP1)
FPG: 
101912524(MINPP1)
FCH: 
102050541(MINPP1)
CLV: 
102099022(MINPP1)
AAM: 
106489037(MINPP1)
ASN: 
102370369(MINPP1)
PSS: 
102458605(MINPP1)
CMY: 
102941827(MINPP1)
CPIC: 
101932598(MINPP1)
ACS: 
100555619(minpp1)
PBI: 
103064022(MINPP1)
GJA: 
107120017(MINPP1)
XLA: 
108696047(minpp1.L) 108697356(minpp1.S)
XTR: 
100493648(minpp1)
DRE: 
394075(minpp1b) 561891(minpp1a)
IPU: 
TRU: 
101067675(minpp1)
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
SASA: 
LCM: 
CMK: 
103180855(minpp1)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
100577002 725931(GB17098)
BIM: 
BTER: 
SOC: 
AEC: 
PBAR: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
OVI: 
NVE: 
ADF: 
HMG: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2) Lj0g3v0197689.3(Lj0g3v0197689.3)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0008s07260g(POPTRDRAFT_765615) POPTR_0010s19200g(POPTRDRAFT_833751)
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os03t0818100-01(Os03g0818100)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
100282868(pco091084)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
CCP: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_059910(101.t00003)
EDI: 
EIV: 
ACAN: 
PIF: 
PSOJ: 
SPAR: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem. J. 259 (1989) 931-3.
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem. J. 328 ( Pt 1) (1997) 75-81.
  Sequence
[rno:29688]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116958-30-6

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