KEGG   ENZYME: 3.1.3.66Help
Entry
EC 3.1.3.66                 Enzyme                                 

Name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase;
inositol-3,4-bisphosphate 4-phosphatase;
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase;
phosphoinositide 4-phosphatase;
inositol polyphosphate 4-phosphatase;
inositol polyphosphate 4-phosphatase type II
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Reaction(KEGG)
R07299;
(other) R04372 R10950
Show
Substrate
1-phosphatidyl-myo-inositol 3,4-bisphosphate;
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549];
phosphate [CPD:C00009]
Comment
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
History
EC 3.1.3.66 created 1992, modified 2002
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01109  
inositol polyphosphate-4-phosphatase
Genes
HSA: 
3631(INPP4A) 8821(INPP4B)
PTR: 
461514(INPP4B) 470448(INPP4A)
PPS: 
100968284(INPP4A) 100989263(INPP4B)
GGO: 
101142456(INPP4A) 101144077(INPP4B)
PON: 
100174369(INPP4B) 100454992(INPP4A)
NLE: 
100592186(INPP4A) 100599079(INPP4B)
MCC: 
699738(INPP4B) 707986(INPP4A)
MCF: 
101865720(INPP4B) 102139378(INPP4A)
CSAB: 
103236308(INPP4B) 103241097(INPP4A)
RRO: 
104661477(INPP4A) 104670159(INPP4B)
CJC: 
100396234(INPP4A) 100408233(INPP4B)
SBQ: 
101038514(INPP4A) 101043111(INPP4B)
MMU: 
234515(Inpp4b) 269180(Inpp4a)
RNO: 
116699(Inpp4b) 80849(Inpp4a)
CGE: 
100767245(Inpp4a) 100771589(Inpp4b)
NGI: 
103742385(Inpp4b) 103744153(Inpp4a)
HGL: 
101718534(Inpp4a) 101719238(Inpp4b)
OCU: 
100340475(INPP4A) 100348588(INPP4B)
TUP: 
102471411(INPP4A) 102477229(INPP4B)
CFA: 
474563(INPP4A) 476072(INPP4B)
AML: 
100482175(INPP4A) 100484540(INPP4B)
UMR: 
103657978(INPP4B) 103671184(INPP4A)
FCA: 
101088920(INPP4A) 101089005(INPP4B)
PTG: 
102959803(INPP4B) 102967296(INPP4A)
BTA: 
534793(INPP4B) 535487(INPP4A)
BOM: 
102283345(INPP4B) 102287496(INPP4A)
PHD: 
102339597 102341210(INPP4A) 102343195(INPP4B)
CHX: 
102180694(INPP4B) 102181043(INPP4A)
OAS: 
101109605(INPP4A) 101112848(INPP4B)
SSC: 
100233232(INPP4A) 100511393(INPP4B)
CFR: 
102523124(INPP4A) 102524318(INPP4B)
BACU: 
102998108(INPP4B) 103010671(INPP4A)
LVE: 
103074180(INPP4A) 103086012(INPP4B)
ECB: 
100051038(INPP4A) 100062978(INPP4B)
MYB: 
102242129(INPP4B) 102249694(INPP4A)
MYD: 
102757149(INPP4B) 102763551(INPP4A)
PALE: 
102883721(INPP4A) 102887805(INPP4B)
LAV: 
100663143(INPP4A) 100670266(INPP4B)
MDO: 
100012162(INPP4A) 100026918(INPP4B)
SHR: 
100918022(INPP4A) 100926247(INPP4B)
OAA: 
100082415(INPP4B)
GGA: 
418690(INPP4A) 422454(INPP4B)
MGP: 
100543360(INPP4B) 100551349(INPP4A)
CJO: 
107307314(INPP4A) 107313162(INPP4B)
APLA: 
101793148(INPP4B) 101797286(INPP4A) 101802644(INPP4A) 101803085
TGU: 
100224898(INPP4B) 100225656(INPP4A)
GFR: 
102039668(INPP4B) 102043062(INPP4A)
FAB: 
101806527(INPP4A) 101812696(INPP4B)
PHI: 
102101814(INPP4A) 102107844(INPP4B)
CCW: 
104686042(INPP4A) 104697266(INPP4B)
FPG: 
101918767(INPP4A) 101920565(INPP4B)
FCH: 
102045868(INPP4B) 102052619(INPP4A)
CLV: 
102083531(INPP4B) 102098823(INPP4A)
AAM: 
106491884(INPP4B) 106494014(INPP4A)
ASN: 
102370491(INPP4B) 102374238(INPP4A)
AMJ: 
102564333(INPP4A) 102575449(INPP4B)
PSS: 
102454053(INPP4B) 102462079(INPP4A)
CMY: 
ACS: 
100551799(inpp4a) 100567592(inpp4b)
PBI: 
103054991(INPP4B) 103059907(INPP4A) 103061669(INPP4B)
GJA: 
107110418(INPP4A) 107115930(INPP4B)
XLA: 
734645(inpp4a)
XTR: 
100496097(inpp4b) 780177(inpp4a)
DRE: 
560006(inpp4b) 792527(inpp4ab)
TRU: 
101062964(inpp4a) 101072250 101078785(inpp4b)
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102348021(INPP4B) 102352456 102360654(INPP4A)
CMK: 
103177132(inpp4a) 103181285(inpp4b)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15857(Dsim_GD15857)
DWI: 
DYA: 
Dyak_GE16121(dyak_GLEANR_17573)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
BMY: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
TAD: 
AQU: 
MBR: 
SRE: 
PSOJ: 
SPAR: 
 » show all
Taxonomy
Reference
1  [PMID:2546770]
  Authors
Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS.
  Title
Evidence for at least four different inositol bisphosphatases in bovine brain.
  Journal
Eur. J. Biochem. 183 (1989) 169-72.
Reference
2  [PMID:7608176]
  Authors
Norris FA, Auethavekiat V, Majerus PW.
  Title
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
  Journal
J. Biol. Chem. 270 (1995) 16128-33.
  Sequence
[hsa:3631] [rno:80849]
Reference
3  [PMID:9295334]
  Authors
Norris FA, Atkins RC, Majerus PW.
  Title
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
  Journal
J. Biol. Chem. 272 (1997) 23859-64.
  Sequence
[hsa:3631 8821] [rno:116699]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
123644-80-4

DBGET integrated database retrieval system