KEGG   ENZYME: 3.1.3.66Help
Entry
EC 3.1.3.66                 Enzyme                                 
Name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase;
inositol-3,4-bisphosphate 4-phosphatase;
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase;
phosphoinositide 4-phosphatase;
inositol polyphosphate 4-phosphatase;
inositol polyphosphate 4-phosphatase type II
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Reaction(KEGG)
R07299;
(other) R04372
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Substrate
1-phosphatidyl-myo-inositol 3,4-bisphosphate;
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549];
phosphate [CPD:C00009]
Comment
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01109  
inositol polyphosphate-4-phosphatase
Genes
HSA: 
3631(INPP4A) 8821(INPP4B)
PTR: 
461514(INPP4B) 470448(INPP4A)
PPS: 
100968284(INPP4A) 100989263(INPP4B)
GGO: 
101142456(INPP4A) 101144077(INPP4B)
PON: 
100174369(INPP4B) 100454992(INPP4A)
MCC: 
699738(INPP4B) 707986(INPP4A)
MMU: 
234515(Inpp4b) 269180(Inpp4a)
RNO: 
116699(Inpp4b) 80849(Inpp4a)
CFA: 
474563(INPP4A) 476072(INPP4B)
AML: 
100482175(INPP4A) 100484540(INPP4B)
FCA: 
101088920(INPP4A) 101089005(INPP4B)
BTA: 
534793(INPP4B) 535487(INPP4A)
SSC: 
100233232(INPP4A) 100511393(INPP4B)
ECB: 
100051038(INPP4A) 100062978(INPP4B)
MDO: 
100012162(INPP4A) 100026918(INPP4B)
SHR: 
100918022(INPP4A) 100926247(INPP4B)
OAA: 
100082415(INPP4B)
GGA: 
418690(INPP4A) 422454(INPP4B)
MGP: 
100543360(INPP4B) 100551349(INPP4A)
TGU: 
100224898(INPP4B) 100225656
ACS: 
100551799(inpp4a) 100567592(inpp4b)
XLA: 
734645(inpp4a)
XTR: 
100496097(inpp4b) 780177(inpp4a)
DRE: 
792527(inpp4ab)
TRU: 
101072250 101078785
OLA: 
101166362
BFO: 
BRAFLDRAFT_204757
CIN: 
100180081
SPU: 
579262
DME: 
Dmel_CG42271
DPO: 
Dpse_GA25798
DAN: 
Dana_GF15990
DER: 
Dere_GG19466
DPE: 
Dper_GL13003
DSE: 
Dsec_GM17564
DSI: 
Dsim_GD15857
DWI: 
Dwil_GK25174
DYA: 
Dyak_GE16121
DGR: 
Dgri_GH12405
DMO: 
Dmoj_GI15856
DVI: 
Dvir_GJ19018
AGA: 
AgaP_AGAP000124
AAG: 
AaeL_AAEL014358
CQU: 
CpipJ_CPIJ018996
AME: 
410061
NVI: 
100116145(NV16003)
TCA: 
655115
API: 
100162521
PHU: 
Phum_PHUM022110
ISC: 
IscW_ISCW022665
BMY: 
Bm1_46610
SMM: 
Smp_081260
NVE: 
NEMVE_v1g87547
TAD: 
TRIADDRAFT_31851
AQU: 
100631688
MBR: 
MONBRDRAFT_18386
 » show all
Taxonomy
Reference
1  [PMID:2546770]
  Authors
Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS.
  Title
Evidence for at least four different inositol bisphosphatases in bovine brain.
  Journal
Eur. J. Biochem. 183 (1989) 169-72.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:7608176]
  Authors
Norris FA, Auethavekiat V, Majerus PW.
  Title
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
  Journal
J. Biol. Chem. 270 (1995) 16128-33.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Reference
3  [PMID:9295334]
  Authors
Norris FA, Atkins RC, Majerus PW.
  Title
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
  Journal
J. Biol. Chem. 272 (1997) 23859-64.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
123644-80-4
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